In humans, the disease cystic fibrosis is caused by a recessive allele for a gene that encodes a specific type of channel protein. Using C as a “normal” allele for the disease, under what conditions is it possible for a child with cystic fibrosis to have biological parents who do not have the disease? Both parents have the genotype Cc It is not possible for this to occur Both parents have the genotype CC

There are two genetic disorders that result from mutation in imprinted genes: Prader-Willi syndrome, Angelman syndrome.  Angelman syndrome results from deletion of UBE3A, which is a gene imprinted such that only the maternal copy is expressed. In the pedigree above, individual I-1 is heterozygous for a deletion of UBE3A and does not have Angelman syndrome.  Individual I-2 is homozygous wild type for UBE3A.  Which individuals in the pedigree are at risk for exhibiting Angelman syndrome, if any?  (Who could potentially have the syndrome, based on what alleles it is possible for them to inherit and express?)   Question 8 options:   Only I-1 could have been at risk.  If he does not have the syndrome, no one in the pedigree could.   Only III-1 is at risk   I-1, II-2, and III-1 are all at risk   Only II-2 is at risk   No one in the pedigree is at risk   Both II-2 and III-1 are at…

I have seen that this was answered as C, Why is the answer C, how is that not evidence of it being genetic? Shouldnt it be none of the above? Question: Of the following, which supports the idea that alcoholism has no genetic or a low genetic component? a) Some strains of mice select alcohol over water 75% of the time, whereas others shun alcohol. b) The concordance value is 55% for MZ twins and 28% for DZ twins. c) Biological sons of alcoholic men who have been adopted have a rate of alcoholism more like that of their adoptive fathers. d) There is a 20% to 25% risk of alcoholism in the sons of alcoholic men. e) None of these.

Explain Maternal effect mutants affecting AP axis patterning

In a wild-type fungus, protein E (encoded by the haplosufficient gene E) normally dimerizes to catalyzes a biochemical reaction necessary for the production of a dark pigment. Ed represents a mutant, dominant negative allele of gene E. What is the predicted phenotype of a fungus cell of genotype E*/Ed, and why? O wild type (normal production of the dark pigment), as E is haplosufficient mutant (no pigment production), as no dimers will form in the heterozygous mutant (no pigment production), as the mutant allele Eg is dominant O wild type (normal production of the dark pigment), as dimers of wild-type and mutant protein E will be formed in the heterozygous

Niemann Pick Type C disease is a recessive disorder that causes the accumulation of cholesterol and other lipids in lysosomes, ultimately affecting both the liver and the nervous system.  Below are the genotypes and phenotypes of offspring of a family with a history of Niemann Pick.  7 NN ( all normal phenotype) 3 Nn  (all normal phenotype) 4  nn (1 early onset dementia, 1 mid-life onset dementia, 2 late-onset dementia).    From this information, Niemann-Pick disease is an example of: A) variable expressivity B) incomplete dominance C) incomplete penetrance D) variable expressivity and incomplete penetrance   E) multiple alleles

Analyze the karyotype shown. Indicate if it is a chromosomal male or achromosomal female. If the karyotype is normal, write the word normal under name or description. If the karyotype is abnormal, name or describethe disorder.