In a study conducted by an undergraduate student, Simran obtained data showing that approximately 75% of the European Northern human population demonstrate the expression of a phenotype directly associated with the homozygous dominant genotype, while 25% display the mutant phenotype despite their genotypes being homozygous dominant. Propose two hypotheses for this observation.

In a study conducted by an undergraduate student, Simran obtained data showing that approximately 75% of the European Northern human population demonstrate the expression of a phenotype directly associated with the homozygous dominant genotype, while 25% display the mutant phenotype despite their genotypes being homozygous dominant. Propose two hypotheses for this observation.

Concepts of Biology

1st Edition

ISBN:9781938168116

Author:Samantha Fowler, Rebecca Roush, James Wise

Publisher:Samantha Fowler, Rebecca Roush, James Wise

Chapter8: Patterns Of Inheritance

Section: Chapter Questions

Problem 11RQ: The ABO blood groups in humans are expressed as the IA,IB and i alleles. The IAallele encodes the A...

See similar textbooks

Similar questions

Propose a hypotheses for this observation: In a study conducted by an undergraduate student, he obtained data showing that approximately 75% of the European Northern human population demonstrate the expression of a phenotype directly associated with the homozygous dominant genotype, while 25% display the mutant phenotype despite their genotypes being homozygous dominant.
Hi, would you plaase answer this question? In a study conducted by an undergraduate student, the obtained data showed that approximately 75% of the European Northern human population demonstrate the expression of a phenotype directly associated with the homozygous dominant genotype, while 25% display the mutant phenotype despite their genotypes being homozygous dominant. Using your knowledge propose two hypotheses for this observation.
In the nematode C. elegans, homozygosity for the e mutant allele causes an extreme "uncoordinated" phenotype, where the worm completely loses its ability to move. Examination of 100 individuals with genotype e/e reveals that 60 mutant worm can't move at all, 35 show a very reduced ability to move, and the remaining 5 seem to have a completely wild-type phenotype with respect to movement ability. These observations suggest that e has O incomplete penetrance and variable expressivity O low expressivity and variable penetrance Ohigh expressivity and variable penetrance O high penetrance and incomplete expressivity
The following data for the genotypes at the alcohol dehydrogenase locus were observed from a sample of Drosophila melanogaster. Sample size 1000 FF 550 FF=0.55; FS=0.34; SS=0.11 O F-0.72; S=0.28 FF=0.078; FS=0.40; SS=0.52 FS What are the Hardy-Weinberg equilibrium genotype frequencies for each genotype based upon this sample? OFF=0.52; FS=0.40; SS=0.078 340 SS 110
A certain form of congenital glaucoma is caused by an autosomalrecessive allele. Assume that the mutation rate is 10-5 and that peoplewith this condition produce, on the average, only about 80% of theoffspring produced by people who do not have glaucoma.a. At equilibrium between mutation and selection, what will the frequencyof the gene for congenital glaucoma be?b. What will the frequency of the disease be in a randomly matingpopulation that is at equilibrium?
APOE gene has been found to be a major contributor to sporadic Alzheimer's disease (AD), by acting as an age-of-onset modifier for the common relatively late-onset forms of the disease. Among four alleles causing early onset of AD, the epsilon4 allele (APOE4) disrupts this function. If you generate transgenic monkeys in which the normal allele of APOE gene is knocked out, what phenotype will you expect for those knockout monkeys? A. The APE mRNA expression will be completely suppressed. B. They slow down the development of AD. C. They develop AD early. D. They don't show any AD symptom.
. The human IGF2 gene is autosomal and maternallyimprinted. Copies of the gene received from themother are not expressed, but copies received fromthe father are expressed. You have found two allelesof this gene that encode two different forms of theIGF2 protein distinguishable by gel electrophoresis.One allele encodes a 60K (Kilodalton) blood protein;the other allele encodes a 50K blood protein. In ananalysis of blood proteins from a couple named Billand Joan, you find only the 60K protein in Joan’sblood and only the 50K protein in Bill’s blood. Youthen look at their children: Jill is producing only the50K protein, while Bill Jr. is producing only the 60Kprotein.a. With these data alone, what can you say about theIGF2 genotype of Bill Sr. and Joan?b. Bill Jr. and a woman named Sara have two children, Pat and Tim. Pat produces only the 60K protein and Tim produces only the 50K protein. Withthe accumulated data, what can you now say aboutthe genotypes of Joan and Bill Sr.?
The use of nucleotide sequence data to measure genetic variabilityis complicated by the fact that the genes of many eukaryotesare complex in organization and contain 5' and 3' flankingregions as well as introns. Researchers have compared thenucleotide sequence of two cloned alleles of the y-globin gene from asingle individual and found a variation of 1 percent. Those differencesinclude 13 substitutions of one nucleotide for anotherand three short DNA segments that have been inserted in oneallele or deleted in the other. None of the changes takes placein the gene’s exons (coding regions). Why do you think this isso, and should it change our concept of genetic variation?
The ABO blood groups in humans are expressed as the IA,IB and i alleles. The IAallele encodes the A blood group antigen, IB encodes B, and i encodes O. Both A and B are dominant to 0. If a heterozygous blood type A parent (IAi) and a heterozygous blood type B parent (IBi) mate, one quarter of their offspring are expected to have the AB blood type IAIBin which both arnigens are expressed equally. Therefore, ABO blood groups are an example of: a. multiple alleles and incomplete dominance b. codominance and incomplete dominance c. incomplete dominance only d. multiple alleles and codominance
Height in humans is controlled by the additive action of genes and the action of environmental factors. For the purposes of this problem, assume that height is controlled by four genesA, B, C, and Dand that there are no environmental effects. Assume further that additive alleles contribute two units of height and partially additive alleles contribute one unit of height. a. Given these assumptions, can two individuals of moderate height produce offspring that are much taller and shorter than either parent? If so, how can this happen? b. Can someone of minimum height and someone of intermediate height have children taller than the parent of intermediate height? Why or why not?
The rosy (ry) gene of Drosophila encodes an enzymecalled xanthine dehydrogenase. Flies homozygous forry mutations exhibit a rosy eye color. Heterozygousfemales were made that had ry41 Sb on one homologand Ly ry564 on the other homolog, where ry41 andry564 are two independently isolated alleles of ry. Ly[Lyra (narrow) wings] and Sb [Stubble (short) bristles] are dominant mutant alleles of genes to the left and right of ry, respectively. These females arenow mated to males homozygous for ry41. Out of100,000 progeny, 8 have wild-type eyes, Lyra wings, andStubble bristles, while the remainder have rosy eyes.a. What is the order of these two ry mutations relativeto the flanking genes Ly and Sb?
Let’s suppose that weight in a species of mammal is polygenic, andeach gene exists as a heavy and light allele. If the allele frequenciesin the population are equal for both types of alleles (i.e., 50%heavy alleles and 50% light alleles), what percentage of individualswill be homozygous for the light alleles in all of the genesaffecting this trait, if the trait was determined by the followingnumber of genes?A. TwoB. ThreeC. Four