Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Related questions
Question
Transcribed Image Text:How does ATP regulate the activity of PFK-1?
ATP binds to PFK-1 at the catalytic site as a competitive inhibitor, decreasing PFK-1 activity.
ATP binds to the allosteric site as an inhibitor, decreasing PFK-1 activity.
ATP binds to the catalytic site as a substrate, increasing PFK-1 activity.
ATP binds to the allosteric site as an activator, increasing PFK-1 activity.
![The graph shows the effect of ATP on the allosteric enzyme phosphofructokinase-1 (PFK-1).
PFK-1 activity (% of Vmax)
100
80
60
40
20
0
Low
[ADP]
[ATP]
High
[ADP]
For a given concentration of fructose 6-phosphate, the PFK-1 activity increases with increasing concentrations of ATP, but there
is a point beyond which increasing the concentration of ATP inhibits the enzyme.](https://content.bartleby.com/qna-images/question/c88ea400-8702-464b-948c-7a80f18e315f/2f4dd910-e591-4c39-a919-f82445f2b081/ymwukk_processed.jpeg)
Transcribed Image Text:The graph shows the effect of ATP on the allosteric enzyme phosphofructokinase-1 (PFK-1).
PFK-1 activity (% of Vmax)
100
80
60
40
20
0
Low
[ADP]
[ATP]
High
[ADP]
For a given concentration of fructose 6-phosphate, the PFK-1 activity increases with increasing concentrations of ATP, but there
is a point beyond which increasing the concentration of ATP inhibits the enzyme.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution
Trending nowThis is a popular solution!
Step by stepSolved in 2 steps
Knowledge Booster
Similar questions
- Which of the following statements is TRUE regarding regulation of glycolyis? hexokinase regulates glycolysis by degrading glucose-6-phosphate low levels of ATP inhibit phosphofructokinase-1 because ATP preferentially binds to the allosteric inhibition site inhibition of glucose-6-phosphate by hexokinase is an example of feedback inhibition none of these statements are correct I selected option C and got it wrong, what is the correct answer with an explanation to why it is and also how was my answer wrong?arrow_forwardwhich answer is falsearrow_forwardThe three irriversible reactions in glycosis is : Hexoknase, PFK-1 and Pryvate kinases. they are all enzymes, why these three enzymes are irriversible? the explaination below is not very understandble. "Hexokinase: This enzyme catalyzes the conversion of glucose to glucose-6-phosphate. This reaction consumes ATP and traps glucose inside the cell by converting it into a charged and phosphorylated form. Phosphofructokinase-1 (PFK-1): This enzyme catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. This reaction is the committed step of glycolysis, and it is also the main regulatory point of the pathway. PFK-1 is allosterically inhibited by ATP and citrate and activated by AMP and fructose-2,6-bisphosphate. Pyruvate kinase: This enzyme catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate, producing ATP. This reaction is the last step of glycolysis and is also highly regulated. Pyruvate kinase is allosterically activated by fructose-1,6-bisphosphate…arrow_forward
- The enzyme PFK was studied in mosquitos. The authors found that: PFK Vmax was 4.5 μmol/min with F-1,6-BP (along with ATP) as the substrates PFK KM using F-1,6-BP and ATP was 1.48 mM F-2,6-BP was a powerful activator for PFK PFK was inhibited by ATP PFK inhibition by ATP could not be overridden by AMP On the graph below, draw: a. A Michaelis-Menten curve for the normal mosquito PFK enzyme b. A Michaelis-Menten curve for the PFK enzyme activated by F-2,6-GP C. A Michaelis-Menten curve for the PFK enzyme inhibited by ATP d. A Michaelis-Menten curve for the PFK enzyme when ATP and AMP are both presentarrow_forwardMatch the descriptions and compounds with the terms competitive, uncompetitive, and noncompetitive inhibition. Competitive inhibition Uncompetitive inhibition Noncompetitive inhibitionarrow_forwardWhat effect is seen on a Lineweaver-Burke graph when a competitive inhibitor is added to an enzymatic reaction? neither the y-intercept nor the slope change both the y-intercept and the slope change the slope of the line changes the line is inversed the y-intercepts changesarrow_forward
- Consider the function of the cofactor FAD. Which of the following makes it unique (different) from NAD+? Select all that apply. O Operates as part of an enzyme and is not a mobile electron carrier O In its fully reduced state, carries 2 electrons OInvolved in electron transfers as part of pyruvate dehydrogenase complex activity O Facilitates single electron transfersarrow_forwardBox lists options: Thioredoxin is: oxidized, reduced activity causes the: inhibition, activation enzymes by: forming, eliminating there is: reduced, oxidized Benson cycle is: more, lessarrow_forwardState and describe the three different types of inhibitors which are competetive, uncompetetive and mixed inhitition. short answer please.arrow_forward
- You experiementally apply the compund antimyctin, which inhinits the functioning of complex III, cytochrome reductase, from participating in redox reactions. You follow this with the addition of 6 molecules of FADH2. How many total ATP molecules can be created using the number of protons that were pumped?arrow_forwardDuring the substrate-level phosphorylation reaction of the TCA cycle, _______________ is phosphorylated to _________________. The energy for this phosphorylation comes from breaking down the _______________________________ bond of _______________________________, releasing a ____________________________ Use the words below CTP CDP GDP Sulfhydryl CoASH Succinyl CoA Acetyl CoA Phosphoanydride α-ketoglutarate GTP Phosphodiester Thioesterarrow_forwardWhat are the effects of different light colors in photosynthesis? Different light colors will change the rate of photosynthesis Light color does not affect photosynthesis Carbohydrates are metabolized by light Photosynthesis does not require lightarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. Freeman
Lehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY 
BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage Learning
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Fundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON
Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY
Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON