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- The conjugate base of diethyl malonate can serve as a nucleophile to attack a wide range of electrophiles. Identify the product that is formed when the conjugate base of diethyl malonate reacts with the following electrophile followed by acid workup when relevant: Modify the provided structures of diethyl malonate and the given electrophile to draw the product formed. Note: the eraser tool can be used to erase bonds, and atoms can be moved by selecting them with the selector tool and then dragging the selected atom(s) to a new position. If you make a mistake, you can use Ctrl-Z or the Undo tool. OH -CH₂ CH₂ Edit DrawingDescribe the given synthetic pathway. Discuss type of reactions involved, the purpose of each reagent, and the relevance of each step. Create a retrosynthetic map for the synthetic pathway in Question 1.The conjugate base of diethyl malonate can serve as a nucleophile to attack a wide range of electrophiles. Identify the product that is formed when the conjugate base of diethyl malonate reacts with the following electrophile followed by acid workup when relevant: Modify the provided structures of diethyl malonate and the given electrophile to draw the product formed. Note: the eraser tool can be used to erase bonds, and atoms can be moved by selecting them with the selector tool and then dragging the selected atom(s) to a new position. If you make a mistake, you can use Ctrl-Z or the Undo tool. бль EtO OEt Edit Drawing
- Describe the given synthetic pathway. Discuss type of reactions involved, the purpose of each reagent, and the relevance of each step. Provide brief explanation. Create a retrosynthetic map for the synthetic pathway in Question 1.Enamines can serve as enolate surrogates in reactions at the a-carbon. In the reaction sequence, the structures of the enamine addition product – the initial zwitterion and its neutral tautomer – are shown. Draw the structures of the two reactants forming these intermediates, and draw the structure of the final product, obtained via hydrolysis of the neutral intermediate. initial zwitterionic intermediate neutral intermediate tautomerization Reactants H,0 hydrolysis product Draw the two reactants. Draw the hydrolysis product. Select Draw Rings More Erase Select Draw Rings More Erase H Hshow the mechanism of the following reaction step by step. Via Fischer esterification and transesterification.
- Enamines can serve as enolate surrogates in reactions at the a-carbon. In the following reaction sequence, the structures of the enamine addition product – the initial zwitterion and its neutral tautomer – are shown. Draw the structures of the two reactants forming these intermediates, and draw the structure of the final product, obtained via hydrolysis the neutral intermediate. reactants initial zwitterionic intermediate tautomerization hydrolysis product neutral intermediate NH н,о Н,о ↑b) Show a complete reaction mechanism for the synthesis of compound K via malonic ester synthesis. Show all the reagents and draw the intermediate structures. COOH Compound Kshow the missing reagents and intermediates in the reaction sequence below
- Provide a retrosynthetic pathway from the following compound. Indicate reagents needed for each transformation...Consider the retrosynthetic sequence shown below. Part: 0/3 Part 1 of 3 OH Br ? Draw the structure of the intermediate compound in the retrosynthetic sequence. Click and drag to start drawing a structure. C™ X 1:0 OH $ tuUsing the retrosynthetic analysis propose a logical route for the following transformation. Draw all substrates, reagents and products