H. Me Call wall bullding block D-Ala-D-Alal-Lys-tail Me Heptapeptide backbone Ri O. R H. R2 i) (lower part) to a bacterial cell wall With the aid of the figure above showing the important features of the binding of Vancomycin eptiadiscuss the antibiotic effect of Vancomycin. iii) Vancomycin resistant strains often have a mutation in which one of the D-Ala moieties is exchanged to a D-lactate moiety. Discuss why this mutation makes the strain Vancomycin- resistant but still viable. iv) Glycoconjugate vaccines based on bacterial capsular polysaccharides have been used for 30 years without any need for changes in their structures, while the flu vaccine, based on attenuated or killed virus particles, requires many different structures and a check each time when there is an epidemic that the right vaccine is used. Discuss the reason behind this.

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Cell wall bullding block
D-Ala-D-Alal-Lys-tail
NH,Me
Heptapeptide
backbone
R1
R.
R2
ii)
With the aid of the figure above showing the important features of the binding of Vancomycin
(lower part) to a bacterial cell wall peptia discuss the antibiotic effect of Vancomycin.
i)
Vancomycin resistant strains often have a mutation in which one of the D-Ala moieties is
exchanged to a D-lactate moiety. Discuss why this mutation makes the strain Vancomycin-
resistant but still viable.
iv)
Glycoconjugate vaccines based on bacterial capsular polysaccharides have been used for 30
years without any need for changes in their structures, while the flu vaccine, based on
attenuated or killed virus particles, requires many different structures and a check each time
when there is an epidemic that the right vaccine is used. Discuss the reason behind this.
Transcribed Image Text:Cell wall bullding block D-Ala-D-Alal-Lys-tail NH,Me Heptapeptide backbone R1 R. R2 ii) With the aid of the figure above showing the important features of the binding of Vancomycin (lower part) to a bacterial cell wall peptia discuss the antibiotic effect of Vancomycin. i) Vancomycin resistant strains often have a mutation in which one of the D-Ala moieties is exchanged to a D-lactate moiety. Discuss why this mutation makes the strain Vancomycin- resistant but still viable. iv) Glycoconjugate vaccines based on bacterial capsular polysaccharides have been used for 30 years without any need for changes in their structures, while the flu vaccine, based on attenuated or killed virus particles, requires many different structures and a check each time when there is an epidemic that the right vaccine is used. Discuss the reason behind this.
Cell wall bullding block
D-Ala-D-Alal-Lys-tail
NH,Me
Heptapeptide
backbone
R1
R.
R2
ii)
With the aid of the figure above showing the important features of the binding of Vancomycin
(lower part) to a bacterial cell wall peptia discuss the antibiotic effect of Vancomycin.
i)
Vancomycin resistant strains often have a mutation in which one of the D-Ala moieties is
exchanged to a D-lactate moiety. Discuss why this mutation makes the strain Vancomycin-
resistant but still viable.
iv)
Glycoconjugate vaccines based on bacterial capsular polysaccharides have been used for 30
years without any need for changes in their structures, while the flu vaccine, based on
attenuated or killed virus particles, requires many different structures and a check each time
when there is an epidemic that the right vaccine is used. Discuss the reason behind this.
Transcribed Image Text:Cell wall bullding block D-Ala-D-Alal-Lys-tail NH,Me Heptapeptide backbone R1 R. R2 ii) With the aid of the figure above showing the important features of the binding of Vancomycin (lower part) to a bacterial cell wall peptia discuss the antibiotic effect of Vancomycin. i) Vancomycin resistant strains often have a mutation in which one of the D-Ala moieties is exchanged to a D-lactate moiety. Discuss why this mutation makes the strain Vancomycin- resistant but still viable. iv) Glycoconjugate vaccines based on bacterial capsular polysaccharides have been used for 30 years without any need for changes in their structures, while the flu vaccine, based on attenuated or killed virus particles, requires many different structures and a check each time when there is an epidemic that the right vaccine is used. Discuss the reason behind this.
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