Glyceraldehyde 3-phosphate + P₁ + NAD+ →→→ 1,3-bisphosphoglycerate + NADH + H+ 1,3-Bisphosphoglycerate + ADP →→ 3-phosphoglycerate + ATP 3-Phosphoglycerate →→→ 2-phosphoglycerate 2-Phosphoglycerate → phosphoenolpyruvate Phosphoenolpyruvate + ADP Pyruvate + NADH + H+ AG'° -31.4 kJ/mol → pyruvate + ATP lactate + NAD+ AG'° = -25.1 kJ/mol Answer Bank AG'° = 4.4 kJ/mol AG'° = 6.3 kJ/mol AG'° = 7.5 kJ/mol AG'° -18.8 kJ/mol

Glyceraldehyde 3-phosphate + P₁ + NAD+ →→→ 1,3-bisphosphoglycerate + NADH + H+ 1,3-Bisphosphoglycerate + ADP →→ 3-phosphoglycerate + ATP 3-Phosphoglycerate →→→ 2-phosphoglycerate 2-Phosphoglycerate → phosphoenolpyruvate Phosphoenolpyruvate + ADP Pyruvate + NADH + H+ AG'° -31.4 kJ/mol → pyruvate + ATP lactate + NAD+ AG'° = -25.1 kJ/mol Answer Bank AG'° = 4.4 kJ/mol AG'° = 6.3 kJ/mol AG'° = 7.5 kJ/mol AG'° -18.8 kJ/mol

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Similar questions

The coenzyme NAD+ is required for which glycolytic reaction shown below? Oglyceraldehyde-3-P→ 1,3-bisphosphoglycerate glucose glucose-6-P fructose-6-P→ fructose-1,6-BP 2-phosphoglycerate → phosphoenolpyruvate
Which reaction below in the glycolytic pathway has a highly unfavorable delta Gº' but a favorable delta G under physiological conditions? 1,3-Bisphosphoglycerate + ADP3-Phosphoglycerate + ATP O2-phosphoglyerate → phosphoenolpyruvate Ofructose-1,6-bisphosphate dihydroxyacetone phosphate + glyceraldehyde-3-phosphate Ofructose-6-phosphate → fructose-1,6-bisphosphate
In which of the following metabolic conversions is ATP “generated” during glycolysis? Phosphoenolpyruvate -> pyruvate 2-Phosphoglycerate —> Phosphoenolpyruvate Glucose-6-phosphate —> Fructose-6-phosphate Fructose-1,6-bisphosphate —> Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate Fructose-6-phosphate —> Fructose-1,6-bisphosphate
Consider the following reaction of the glycolysis pathway. Which statement is NOT true regarding this reaction? P + C-H NADH + H+ NAD+ C-0-P H-C-OH H-C-OH Glyceraldehyde- CH₂0-P 3-phosphate dehydrogenase CH₂0-P 1,3-Bisphosphoglycerate Glyceraldehyde-3- phosphate O A one-carbon compound (1C) is converted into a two-carbon compound (2C). O It requires a coenzyme. O It is a redox reaction catalyzed by the enzyme glyceraldehyde-3-phosphate dehydrogenase. O It is a phosphorylation reaction.
Indicate the general type of enzyme that mediates each glycolysis reaction depicted below. (e.g. Transferase, Oxidoreductase, Kinase, Hydrolase, Lyase, or Isomerase) iii. O H Glyceraldehyde-3-phosphate → 1,3-Bisphosphoglycerate H-C-OH + NAD CH₂O-P + P₁ H-O- -C-H Glucose →→ Glucose-6-phosphate H b 0 OH HO OH H-C- 0 -H HO- H ОН H-C-OH + NADH +H+ CH₂O P P ATP ADP 1 H (P-O- -C- H H HO OH 2-Phosphoglycerate → Phosphoenolpyruvate 0 OH H ОН -O~(P) + HOH
The table lists the standard free energies (AG°') of hydrolysis of some phosphorylated compounds. Compound Phosphoenolpyruvate (PEP) 1,3-Bisphosphoglycerate (1,3-BPG) Creatine phosphate ATP (to ADP) Glucose 1-phosphate Pyrophosphate (PP;) Glucose 6-phosphate Glycerol 3-phosphate kJ mol-¹ -61.9 -49.4 -43.1 -30.5 -20.9 -19.3 -13.8 -9.2 kcal mol-1 -14.8 -11.8 -10.3 -7.3 -5.0 -4.6 -3.3 -2.2
Glyceraldehyde-3-phosphate + NAD+ + Pi → 1,3-bisphosphoglycerate + NADH + H+ ∆G0’ =+6.3 kJ mol-1 ② NAD+ + H+ + 2e- → NADH ∆G0’ = +61.7 kJ mol-1 ③ Glyceraldehyde-3-phosphate + Pi → 1,3-bisphosphoglycerate + H+ + 2 e- ∆G0’ = ??? kJ mol-1 How are equations ② and ③ related to equation ①? b) Calculate the ∆G0’ for the formation of 1,3-bisphosphoglycerate from glyceraldehyde-3-phosphate and inorganic phosphate (reaction ③ above) c) Why is reaction ③ coupled with the reaction ② when reaction ② is so unfavorable, i.e., what is the chemical role of the NAD+?
C Phosphoglycerate enolase coo O H-C-O-P=O CH₂OH 2-Phosphoglycerate This is a (an) d Tyrosine hydroxylase HO coo NH3 L-Tyrosine This is a (an) 0₂ coo C-O-P-C || CH₂ Phosphoenolpyruvate H₂O + HO HO L-DOPA H₂O coo NH3
In which of the following metabolic conversions is ATP “generated” during glycolysis? Glucose —> Glucose-6-phosphate 1,3-Bisphosphoglycerate —> 3-Phosphoglycerate Fructose-1,6-bisphosphate —> Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate Glucose-6-phosphate —> Fructose-6-phosphate 2-Phosphoglycerate —> 3-Phosphoglycerate
A figure of the energy payoff phase of glycolysis is shown below. Look at the reaction labelled with a 6 (on the far left), which involves the conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate. reduced? HC O CHOH CH₂O-P Glycer- aldehyde 3-phosphate (G3P) 2 NADH 2 NAD+ + 2 H+ Triose phosphate 2 P₁ dehydrogenase Copyright © 2018 Pearson Canada Inc. P CHOH CH₂0-P 1,3-Bisphospho- glycerate 1,3- bisphosphoglycerate NADH NAD+ 2 ADP GLYCOLYSIS: Energy Payoff Phase Glyceraldehyde-3-phosphate 2 ATP Phospho- glycerokinase 2 Which of the compounds is C=O CHOH H–CO- P Phospho- CH₂0-P glyceromutase CH₂OH 8 3-Phospho- glycerate C=O 2-Phospho- glycerate 2. ATP 2 ADP BYD Pyruvate kinase 10 2 H₂O Enolase 2 C=O CO-P CH2 Phosphoenol- pyruvate (PEP) CH3 Pyruvate
Which of the following is the correct summary of phase II of glycolysis for each molecule of glucose? Glucose + ATP ⟶ Glyceraldehy-3-phosphate + ADP Glucose + 2 ATP ⟶ 2(Glyceraldehy-3-phosphate) + 2 ADP Glyceraldehyde-3-phosphate + NAD+ + ADP + Pi ⟶ 3-phosphoglycerate + NADH + H+ + ATP 2(3-phosphoglycerate) + 2ADP ⟶ 2 pyruvate + 2ATP 2(Glyceraldehyde-3-phosphate) + 2NAD+ + 2ADP + 2Pi ⟶ 2(3-phosphoglycerate) + 2NADH + 2H+ + 2ATP
Pair the reactions mentioned on the left with the names of the enzymes on the right. 1,3-bisphosphoglycerate to 3-phosphoglycerate [ Choose ] [ Choose ] 3-Phosphoglycerate to 2-Phosphoglycerate Phosphoglucoisomerase Phosphoglycerate kinase Pyruvate Kinase Glucose-6-P to Fructose-6-P Phosphoglyceromutase Triose phosphate isomerase Dihydroxyacetone phosphate to Glyceraldehyde [ Choose ] 3-Phosphate Phosphoenolpyruvate to Pyruvate [Choose ]