For three years, Gunther Schlager and Margaret Dickie estimated theforward and reverse mutation rates for five loci in mice that encodevarious aspects of coat color by examining more than 5 million mice forspontaneous mutations (G. Schlager and M. M. Dickie. 1966. Science151:205–206). They detected the following numbers of mutations at thedilute locus: Gametes examined Mutations detectedForwardmutations 260,675 5Reversemutations 583,360 2 Calculate the forward and reverse mutation rates at this locus. If thesemutations rates are representative of rates in natural populations of mice,what would the expected equilibrium frequency of dilute mutations be?
For three years, Gunther Schlager and Margaret Dickie estimated the
forward and reverse mutation rates for five loci in mice that encode
various aspects of coat color by examining more than 5 million mice for
spontaneous mutations (G. Schlager and M. M. Dickie. 1966. Science
151:205–206). They detected the following numbers of mutations at the
dilute locus:
Gametes examined Mutations detected
Forward
mutations 260,675 5
Reverse
mutations 583,360 2
Calculate the forward and reverse mutation rates at this locus. If these
mutations rates are representative of rates in natural populations of mice,
what would the expected equilibrium frequency of dilute mutations be?
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