Because of the relatively high frequency of meiotic errors that lead to developmental abnormalities in humans, many research efforts have focused on identifying correlations between error frequency and chromosome morphology and behavior. Tease et al. (2002) studied human fetal oocytes of chromosomes 21, 18, and 13 using an immunocytological approach that allowed a direct estimate of the frequency and position of meiotic recombination. Below is a summary of information [modified from Tease et al. (2002)] that compares recombination frequency with the frequency of trisomy for chromosomes 21, 18, and 13. (Note: You may want to read appropriate portions of Chapter 8 for descriptions of these trisomic conditions.) Trisomic Mean Recombination Frequency Live-born Frequency Chromosome 21 1.23 1/700 Chromosome 18 2.36 1/3000–1/8000 Chromosome 13 2.50 1/5000–1/19,000 (a) What conclusions can be drawn from these data in terms of recombination and nondisjunction frequencies? How might recombination frequencies influence trisomic frequencies? (b) Other studies indicate that the number of crossovers per oocyte is somewhat constant, and it has been suggested that positive chromosomal interference acts to spread out a limited number of crossovers among as many chromosomes as possible. Considering information in part (a), speculate on the selective advantage positive chromosomal interference might confer.
Because of the relatively high frequency of meiotic errors that lead
to developmental abnormalities in humans, many research efforts
have focused on identifying correlations between error frequency
and chromosome morphology and behavior. Tease et al. (2002)
studied human fetal oocytes of chromosomes 21, 18, and 13 using
an immunocytological approach that allowed a direct estimate of
the frequency and position of meiotic recombination. Below is a
summary of information [modified from Tease et al. (2002)] that
compares recombination frequency with the frequency of trisomy
for chromosomes 21, 18, and 13. (Note: You may want to read
appropriate portions of Chapter 8 for descriptions of these trisomic
conditions.)
Trisomic Mean Recombination
Frequency
Live-born
Frequency
Chromosome 21 1.23 1/700
Chromosome 18 2.36 1/3000–1/8000
Chromosome 13 2.50 1/5000–1/19,000
(a) What conclusions can be drawn from these data in terms
of recombination and nondisjunction frequencies? How might
recombination frequencies influence trisomic frequencies?
(b) Other studies indicate that the number of crossovers per
oocyte is somewhat constant, and it has been suggested that
positive chromosomal interference acts to spread out a limited
number of crossovers among as many chromosomes as possible.
Considering information in part (a), speculate on the selective
advantage positive chromosomal interference might confer.
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
