Q: Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb? If so, how…
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Q: Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to…
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Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…
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Q: What are Two kinds of cancer-producing mutations?
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Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…
A: Genetic transformation happens when the genetic composition of an organism is transformed by the…
Q: Which of the following is NOT an example of fail-safe mechanisms that prevent the irregular cell…
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Q: If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking…
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Q: Why do mutations in DNA repair genes increase the likelihood of developing cancer?
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Q: Which of the following is NOT an example of a fail-safe mechanism that prevents the irregular cell…
A: Uncontrolled cell division results in the development of a tumor or cancer. There are many factors…
Q: What is the difference between an oncogene and a tumor-suppressorgene? Give two examples of each…
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Q: How cancer is genetic diseases, in spite of the fact that most cancers are not inherited?
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Q: terms of genetics --- What is cancer, how is it initiated, maintained
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Q: Please distinguish driver and passenger mutations in cancer.
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Q: What separates cancer cells from normal cells?
A:
Q: True or False: Cancers develop when many mutations develop rather than from a single mutation
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Q: In DNA repair, how does the normal allele of BRCA1 work? Is it an oncogene or a tumor suppressor…
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Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…
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For a gene to be cancer-inducing, both copies of the gene must be affected, explain it with example.
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- Describe two mechanisms by which genetic change causes cancer.Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please list item by item. Explain in detail the main findings."In the cellular regulatory pathways that control cell growth and proliferation, the products of oncogenes are stimulatory components and the products of tumor suppressor genes are inhibitory components" is true or false.
- Name one type of gene that leads to cancer when it is mutated.Why is it important to model cancer through the generation of induced pluripotent stem cells ? Explain in detail the main findings. Please sort as a list.What separates cancer cells from normal cells? Describe one form of mutation that can increase the risk of a normal cell being cancerous.
- "once cells have differentiated to their final specialized forms, they never again alter expression of their genes" is true or false.Which of the following effectively describes the situation of someone with an inherited predisposition to cancer such as familial adenomatous polyposis or BRCA-associated familial breast cancer? Choose all that apply a) If they get malignant cancer, somatic mutations will not have been a factor b) Their cancer will most likely arise in their germ cells, not their somatic cells c) None of the answers effectively describes the situation d) Every cell of their body contains a gain-of-function allele of an oncogene e) Most cells in their body contain multiple cancer-causing mutations f) Every cell of their body contains a defective, loss-of-function allele of a tumor suppressor gene(b): How many forms can naturally occurring DNA exist in? Explain how these forms are characterized. What properties of the functional groups determine the binding of DNA with anti-cancer agents? Explain.
- D) The level of carbon dioxide increases with the level of available oxygen. 60) The TP53 gene provides instructions for making a protein called tumor protein p53. Known as the guardian of the genome, this protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way. The p53 protein is located in the nucleus of cells throughout the body, where it attaches directly to DNA and plays a critical role in determining whether the DNA will be repaired or the damaged cell will self- destruct (undergo apoptosis). If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. eg Suppose chromosomes in a skin cell are damaged by ultraviolet radiation. If the damaged genes do not affect p53, which choice correctly predict if the cell will become cancerous and why? No, the cell will…There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA stability/repair genes. Define each of these categories and indicate which one you think the RB1 gene belongs to and why.Describe the five hallmarks of tumor cells and explain how each is required for transformation.