Explain one of the mechanisms discussed in class by which a person’s genetics may be correlated with their microbiome composition. Can you think of any confounders to this interaction?
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Explain one of the mechanisms discussed in class by which a person’s genetics may be correlated with their microbiome composition. Can you think of any confounders to this interaction?
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- Penicillin was first used in the 1940s to treat gonorrhea infections produced by the bacterium Neisseria gonorrhoeae. In 1984, according to the CDC, fewer than 1% of gonorrhea infections were caused by penicillin-resistant N. gonorrhoeae. By 1990, more than 10% of cases were penicillin resistant and a few years later the level of resistance was 95%. Explain the various ways this resistance could be spread among the cells. Could this resistance pass to other infectious bacteria from N. gonorrhoeae?This article highlights a young doctor at Elmhurst Hospital during the beginning of Covid-19 pandemic. Dr. Zikry is quoted as saying: “It’s become very clear to me what a socioeconomic disease this is...”. In addition, the textbook discusses the personal variables and socioeconomic status (SES) that are used to find patterns in disease (pp.112-118). What do you think Dr. Zikry meant by referring to the SES of his patients? Why was it important to find a pattern of personal variables and SES among the of victims of Covid-19 at the beginning of the pandemic?Assume you are studying the infection dynamics between a species of spider and a species of ringworm that infects the spider. You sequence the genomes of each species for 30 years and find that each of these species has evolved adaptations. Specifically, the spider has evolved immune system adaptations to remove the ringworm and the ringworm has evolved counter-adaptations to evade the spider's immune system. Surprisingly, you find that the ability of the ringworm to infect the spider has not changed over 30 years. The finding that infectiousness has not changed in 30 years would be in support of which of the following? a. The Red Queen Hypothesis b. Muller's Ratchet c. The Asexual Reproduction Benefit Hypothesis d. The Genetic Load Hypothesis
- An outbreak of Ebola between 2014 and 2016 resulted in 28,616 cases and 11,310 deaths in Guinea, Liberia and Sierra Leone. An additional 36 cases and 15 deaths were reported outside these 3 countries. This deadly disease urged the need for extensive research on Ebola to better understand and treat the disease and prevent future outbreaks. Ebola is a - SSRNA virus. What does this mean for how it is converted into proteins? Does this virus require additional machinery to be infectious? Can you hypothesize based on how it replicates in the cell what scientists might hope to target for treatment or prevention of Ebola?A government official interested in determining the number of infants affected with the human immunodeficiency virus (HIV) has approached your hospital to participate in a statewide funded study. The protocol will include the testing of all newborns for HIV, but the mothers will not be told that the test is being done, nor will they be told the results? Using the basic ethical principles (available in the resources file), defend or refute the practice. How will the findings of the proposed study be affected if the protocol is carried out?In 2013, there was an outbreak of methicillin-resistant Staphylococcusaureus (MRSA) at an NFL training facility. One player suffereda career-ending infection to his foot and sued the team owners for $20 million for unsanitary conditions that contributed to the bacterialinfection. A settlement with undisclosed terms was reached in2017. MRSA is highly contagious and is spread by direct skin contactor by airborne transmission and can result in amputation or death.In addition, MRSA is very difficult to treat because it is resistant tomany antibiotics. For example, b -lactam antibiotics, such as penicillin,function by binding to and inactivating bacterial penicillin-bindingproteins (PBPs), which synthesize the bacterial cell wall. However,MRSA expresses an alternative type of PBP, called PBP2a encodedby the mecA gene. b -lactam antibiotics only weakly bind PBP2a,and thus cell wall synthesis can continue in their presence. Moreover,in a system somewhat analogous to the regulation of the…
- Griffith's Experiments using Streptococcus pneumonia rough and smooth strains concluded which of the following? a) DNA is the Molecule of Inheritance b) Some, yet unknown, factor of inheritance could be transferred from one bacteria to another. c) Protein if the Molecule of Inheritance d) Heat treating bacteria has NO effect on its virulenceIn 2013, there was an outbreak of methicillin-resistant Staphylococcusaureus (MRSA) at an NFL training facility. One player suffereda career-ending infection to his foot and sued the team owners for $20 million for unsanitary conditions that contributed to the bacterialinfection. A settlement with undisclosed terms was reached in2017. MRSA is highly contagious and is spread by direct skin contactor by airborne transmission and can result in amputation or death.In addition, MRSA is very difficult to treat because it is resistant tomany antibiotics. For example, b -lactam antibiotics, such as penicillin,function by binding to and inactivating bacterial penicillin-bindingproteins (PBPs), which synthesize the bacterial cell wall. However,MRSA expresses an alternative type of PBP, called PBP2a encodedby the mecA gene. b -lactam antibiotics only weakly bind PBP2a,and thus cell wall synthesis can continue in their presence. Moreover,in a system somewhat analogous to the regulation of the…In 2013, there was an outbreak of methicillin-resistant Staphylococcusaureus (MRSA) at an NFL training facility. One player suffereda career-ending infection to his foot and sued the team owners for $20 million for unsanitary conditions that contributed to the bacterialinfection. A settlement with undisclosed terms was reached in2017. MRSA is highly contagious and is spread by direct skin contactor by airborne transmission and can result in amputation or death.In addition, MRSA is very difficult to treat because it is resistant tomany antibiotics. For example, b -lactam antibiotics, such as penicillin,function by binding to and inactivating bacterial penicillin-bindingproteins (PBPs), which synthesize the bacterial cell wall. However,MRSA expresses an alternative type of PBP, called PBP2a encodedby the mecA gene. b -lactam antibiotics only weakly bind PBP2a,and thus cell wall synthesis can continue in their presence. Moreover,in a system somewhat analogous to the regulation of the…
- In the Spring and Summer of 2020, mass protests erupted across the US in response to police violence against African Americans. At the same time, the US was experiencing a COVID-19 pandemic. Many public health experts wondered whether participating in these protests (exposure) would be associated with being diagnosed with COVID-19 (outcome). Imagine you have been hired to draft a plan to study this potential association. There are many parts of the discussion. Be sure to answer all questions. • Which study design would you choose? (Almost any design is okay). Explain the factors that influenced why you selected that one. Include some of the benefits/drawbacks of your selected study design and the benefits/drawbacks of ONE of the study designs you did not select. • Write your research question and make a hypothesis about the results. • Research question should be neutral. Do not include words such as "increases" or "decreases." • Hypothesis can include words such as "increases" or…In a case study, scientists frequently infer that Malignant transformation of hymenolepis nana in human host occurred because of the patient’s HIV/AIDS status and resultant immunocompromised state. When N=1, is such an inference statistically justified? In addition to Yes or No, jot down your thoughts on the possible association between AIDS and this case.Gonorrhea is a sexually transmissible disease (STD) caused by the bacterium Neiserria gonorrhoeae. In the 1940s, penicillin was introduced as an antibiotic to treat gonorrhea. In particular, the drug inhibits the formation of new cell walls in dividing bacterial cells, making new cells vulnerable to the human body's defences. However, a new strain of Neiserria gonorrhoeae was found that is capable of breaking down penicillin, making this strain resistant. The emergence of this new strain has been associated with instances of non-strict compliance of certain patients on the use of penicillin as well as the improper administration of the drug. Based on the information given, formulate a strategy that could help control this new strain.