Enalapril is inactive until acted upon by an esterase. Draw the structure of the resulting bioactive derivative.

Q: Draw in detail the pathway of de novo synthesis of deoxythymidine phosphate and provide a brief…

A: First carbamoyl phosphate is synthesized , which then enters the de-novo synthesis pathway for…

Q: Radioactive uracil can be used to label all of the pyrimidine residues inDNA. Using either names or…

A: Allosteric regulation is the regulation of an enzyme by binding an effector molecule at a site other…

Q: What is the biochemical relevance of cori cycle

A: Introduction: The chemical reactions that occur within the living body for the production of energy…

Q: Gemcitabine is a deoxycytidine analog used in treating pancreatic and ovarian cancer. The drug…

A: Gemcitabine  It is a chemotherapy medicine used in the treatment of various cancers. It is a…

Q: Write the mechanism (in detail) for the conversion of aspartate and carbamoyl phosphate into N -…

A: Aspartate carbamoyl transferase helps in the initial step of biosynthetic pathway of pyrimidine…

Q: What method and conditions (provide detail) do you propose to measure the Specific Activity of the…

A: Specific activity is the degree of purity of the enzyme, which measures the enzyme activity and the…

Q: Propose a metabolic I pathway for methotrexate

A: Methotrexate and its active polyglutamate metabolites interfere with several intracellular metabolic…

Q: Using the catalytic mechanism of serine proteases, draw and label a reaction coordinate…

A: In order to draw the reaction coordinate diagram of the chymotrypsin catalyzed hydrolysis of a…

Q: Gerhart and Pardee measured ATCase activity in the presence of a variety of purine and pyrimidine…

A: Aspartate Transcarbamylase is an enzyme which regulate early step in synthesis of pyramidine…

Q: How can you recognize an enzyme that does not display Michaelis–Menten kinetics?

A: Enzymes are proteins that catalysis a biochemical reaction. Enzymes are restored after the reaction.…

Q: cyclophosmamide

A:

Q: Predict the locations of 14C in Aspartate synthesis using the following labeled 14C succinate.

A: Given, Structure of radio label succinate: -OO14C-CH2-14CH2-14COO- Succinate is an intermediate of…

Q: What is polyubiquitinylation?

A: The cells are made to respond to environmental stresses by various cellular mechanisms. These…

Q: Explain why several biochemical pathways start by putting a coenzyme A onto the molecule that…

A: For the functioning of an enzyme, a non-protein compound is usually needed. They loosely bind to…

Q: Considering the general structure of penicillins, how are they rendered ineffective?   Select…

A: Penicillin is an antibiotic that inhibits the formation of peptidoglycan cross-links of the…

Q: Part C Elastase is closely related to chymotrypsin. Suggest two kinds of amino acid residues you…

A: there are four classes of biological macromolecules: nucleic acids, proteins, lipids and…

Q: How is the glycerol 3-phosphate required for phosphatidate synthesis generated?

A: Phosphatidate is a necessary biomolecule because phospholipids, which are essential components of…

Q: X-ray crystallographic studies of ATCase in the R form required the use of the bisubstrate analog…

A: ATCase (Aspartate Transcarbamoylase) is an enzyme regulated allosterically with unique quaternary…

Q: You perform Michaelis-Menten kenetics on i) trypsin and ii) a mutant form of the same enzyme (a…

A: Specificity constant is the quotient of Km / kcat. A large kcat indicates a less efficient enzyme…

Q: Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the…

A: Nucleotides are ubiquitous as they are involved in majority of biochemical reactions. All of the…

Q: α-Keto acids are sometimes used nutritionally. Justify.

A: α-Keto acids are the organic compounds that are involved in biological reactions such as the Krebs…

Q: Which of the following statements is not true about the catalytic triad in chymotrypsin?  Group of…

A: The objective of the question is to identify the incorrect statement about the catalytic triad in…

Q: What is the importance in glycosylation in rtPA in terms of its activity as a protein therapeutic?

A: Tissue plasminogen activator (tPA) is a serine protease that catalyzes the formation of plasmin…

Q: Describe a common feature at the active site of serine proteases and acetyl cholinesterase

A: Acetylcholinesterase is an enzyme that catalyzes the hydrolysis of acetylcholine (which is a…

Q: ubiquitin attaches to proteins via many biochemical reactions, please explain how this attachment…

A: Ubiquitin is a highly conserved 76-residue monomeric protein found in eukaryotes. It is found in…

Q: Dihydrouracil and β-ureidopropionate (N-carbamoyl–β-alanine) are intermediates in the conversion of…

A: The non-essential amino acid is referred to as beta-alanine. This amino acid produced in the body…

Q: Draw the detailed mechanism of the transamination reaction in the active site of an…

A: Transamination reaction involves transfer of an amino group to a ketoacid to form new amino acids.…

Q: What is the purpose of dideoxyribonucleoside triphosphates, or ddNTPs?

A: DdNTPs are called as dideoxynucleotides triphosphates. It includes 4 types of nucleotides i.e…

Q: Construct the mechanism of a serine-protease with a catalytic triad.

A: A serine protease is an enzyme that cleaves peptide bonds in proteins and peptides. It possesses a…

Q: The formation of the acyl-enzyme complex in chymotrypsin is through a ------------- reaction between

A: Enzymes are known as biological catalysts that help to catalyze the different biochemical reactions…

Q: Why Cepacol is used ?

A: Cepacol is a drug which relieves pain associated with a sore throat or mouth. It can be administered…

Q: Why does activation of the phosphorylated b form of glycogen synthase by high concentrations of…

A: Glucose metabolism is one of the most important metabolic pathways in living organisms. Glucose is…

Q: Why should phenylketonurics avoid using aspartame, an artificial sweetener? (Hint: Aspartame is…

A: Introduction Phenylketonuria (PKU) is a rare genetic condition in which the amino acid phenylalanine…

Q: Two therapeutics, methotrexate and fluorouracil, inhibit the formation of dTMP, at different points…

A: Methotrexate also known as amethopterin is anticancer agent and immune system suppressing agent.…

Q: Why is de novo biosynthesis of purines markedly elevated in patients with a deficiency in…

A: HGPRT is an important enzyme in the recycling of building blocks of nucleic acids like DNA or RNA.…

Q: Methotrexate used in chemotherapy? How does it work in terms of enzyme inhibition that is involved…

A: Methotrexate- is an anti-cancer chemotherapy drug. It is one of a group of chemotherapy drugs called…

Q: Discuss the role of feedback inhibition in the anabolism ofpurine-containing nucleotides.

A: DNA and RNA are two different forms of nucleic acids, which are biological polymers of monomer units…