Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Construct the mechanism of a serine-protease with a catalytic triad.
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- Classify the following enzymes: Oxidoreductase, Hydrolase, Transferase, Lyase, Ligase, Isomerase 1. Sucrase - 2. Trypsin - 3. Catalase - 4. Aspartate aminotransferase - 5. Cellulase - 6. Ptyalin - 7. Lactase - 8. Creatinine phosphokinase - 9. 5- alpha reductase - 10. Aminopeptidase -arrow_forwardIn the salvage of purines, hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is responsible for which of the following processes? Conversion of hypoxanthine to xanthine Conversion of adenine to adenosine monophosphate (AMP) Conversion of guanine to guanosine monophosphate (GMP) Conversion of inosine monophosphate to inosinearrow_forwardFrom the complete oxidation of glucose (glucose → 6CO2), how many total nucleotide triphosphates are yielded (be sure to deduct payback) as part of substrate level phosphorylation?arrow_forward
- What type of reactions would involve a ligase? neither anabolic nor catabolic anabolic exergonic catabolicarrow_forwardSuppose you discover that bacteria that express OmpF have concentrations of <0.1uM of ciprofloxacin in the cytosol but those without this substance have concentrations of up to 50uM in the cytosol by the time they die. What does this tell you about the function of the isolated substance, OmpF, which you suspected from the start was related to quinolone resistance? How is the OmpF structure optimized for this function? Which amino acids in OmpF are suited to each aspect of its function? The structure of ciprofloxacin is shown below for reference.arrow_forward1. A) Explain this statement, “Most enzymes are gene-encoded proteins, but most enzymes are not only protein". B) You recently isolated a new enzyme in your lab, and you named it "lipidase 1120". As a temporary name, this is fine. Who is responsible for assigning a formal name, and on what criteria will that name be assigned?arrow_forward
- What is the committed step of pyrimidine biosynthesis? Include the names and structures of any product(s), substrate(s), and cofactors, and the name of the enzyme responsible.arrow_forwardIn which two ways does the ribulose monophosphate pathwaysave energy over reactions of the serine pathway?arrow_forwardWhich statement is true for the active site residues of RNase A, lysozyme, or trypsin? Select any/all answers that apply. O A. His12 (RNase A) initially acts as an acid. O B. His119 (RNase A) initially acts as an acid. O C. Glu35 (lysozyme) initially acts as an acid. O D. His57 (trypsin) initially acts as an acid. O E. Ser195 (trypsin) initially acts as an acid.arrow_forward
- Can you answer all the parts to this question please A. Where does a low barrier hydrogen bond (LBH) form transiently during the serine protease mechanism? B. What part does this LBH play in the serine protease mechanism?arrow_forwardThe biosynthetic pathway for the two amino acides E and H is shown schematically in the Figure below: A W E 2 Z H How would this pathway change if C was mutated and non-functional?arrow_forwardExplain the role that Gla residues play in complexes. Explain the role of vitamin K / warfarins in the synthesis of protease factors and list the Vitamin K-dependent factorsarrow_forward
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