Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Explain why several biochemical pathways start by putting a coenzyme A onto the molecule that initiates the pathway.
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- Why must metabolic pathways be regulated? Cite three ways by which metabolic pathways are regulated.arrow_forwardWhat type of enzyme regulation is the most readily (quickly) reversible?arrow_forwardFor the three biochemical transformations below provide the names of the enzyme (or enzymes) responsible for the transformation, and identify by name or chemical structure the other necessary reactants and other products associated with each transformation. Make sure that your answer presents the missing information in a way that clearly connects it to the appropriate reaction.arrow_forward
- The products of a pathway, or the products of specific reactions in the pathway, will often inhibit upstream regulatory enzymes in that pathway. That makes sense - if the products of a pathway are abundant, then the pathway can be shut off to save energy or divert molecules into other pathways. We can use a similar rule of thumb to predict whether a pathway will be active in different biological states. For example, the liver stores glucose (in the form of glycogen), and will release glucose into the bloodstream when blood sugar levels drop. This glucose can come from the synthesis of glucose or breakdown of stored glycogen. This is important for maintaining blood sugar levels. What would you predict is the relationship between blood sugar levels and glycogen phosphorylase enzyme activity? A positive relationship (when blood sugar levels are high, glycogen phosphorylase activity is also high). A negative relationship (when blood sugar levels are high, glycogen phosphorylase activity…arrow_forwardwhy is the pathway for biosynthesis of a biomolecule at least partially different than the pathway for catabolism.arrow_forwardif there are twelve different intermediate products produced in the stage of a metabolic within a cell, we can expect that therearrow_forward
- The natural enzyme is recreated by mixing isolated regulatory and catalytic subunits of ATCase. What biological relevance does this observation have?arrow_forwardExplain why enzymes may need an organic cofactor derived from a vitamin( i.e.,a coenzyme) or mineral cofactor to functionarrow_forwardAmong the following biochemical condition, which condition describes forward (spontaneous) reaction? a) Q >> Keq b) ΔΔG=0 c) Keq=1 d) Q << Keqarrow_forward
- Explain why it is normal for two enzymes that have vastly different amino acid sequences, still be able to catalyze similar enzymatic reactions.arrow_forwardWhy can’t an enzyme use an induced fit mechanism to achieve catalytic perfection?arrow_forwardExplain IN DETAIL the process of Kreb’s Cycle. Include the overall equation, location, products, by-products, and reactants.arrow_forward
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