Does a molecular marker have to be polymorphic to be useful in physical mapping studies? Does a molecular marker have to be polymorphic to be useful in linkage mapping (i.e., involving family pedigree studies or genetic crosses)? Explain why or why not.

Does a molecular marker have to be polymorphic to be useful in physical mapping studies? Does a molecular marker have to be polymorphic to be useful in linkage mapping (i.e., involving family pedigree studies or genetic crosses)? Explain why or why not.

Name: Does a molecular marker have to be polymorphic to be useful in physica
Uploaded: 2024-03-20T06:43:04.000Z
Channel: Bartleby
Description: Does a molecular marker have to be polymorphic to be useful in physical mapping studies? Does a molecular marker have to be polymorphic to be useful in linkage mapping (i.e., involving family pedigree studies or genetic crosses)? Explain why or why n

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 10QP: A proband female with an unidentified disease seeks the advice of a genetic counselor before...

See similar textbooks

Similar questions

What advantages do anonymous DNA markers afford for genetic mapping as opposed to traditional allelic markers associated with visible phenotypes? What are the disadvantages of anonymous DNA markers for mapping?
You have already localized the genes to the same chromosome by deletion mapping, and now decide that the best way to accomplish the mapping is to conduct two simultaneous three-point testcross experiments. The genes you are investigating are as follows: N = round leaves, n = notched leaves; H = smooth stems, h = hairy stems; R = purple flowers, r = red flowers; B = grey seeds, b = black seeds; and Y = green pods, y = yellow pods. Earlier experiments you have done already established that gene B is in the middle of this gene cluster, so you design both three-point test crosses to include that gene. Cross #1 is designed as RrHhBb x rrhhbb while cross #2 is NnBbYy x nnbbyy. The results of both crosses are given in the table below. Based on the information given, determine the arrangement of these five genes including the position of each allele in the heterozygous fly and the distances between each pair of genes. (Hint: treat each experiment separately, knowing that gene B is in the…
Pedigree Analysis Is a Basic Method in Human Genetics Using the pedigree provided, answer the following questions. a. Is the proband male or female? b. Is the grandfather of the proband affected? c. How many siblings does the proband have, and where is he or she in the birth order?
A proband female with an unidentified disease seeks the advice of a genetic counselor before starting a family. Based on the following data, the counselor constructs a pedigree encompassing three generations: (1) The maternal grandfather of the proband has the disease. (2) The mother of the proband is unaffected and is the youngest of five children, the three oldest being male. (3) The proband has an affected older sister, but the youngest siblings are unaffected twins (boy and girl). (4) All the individuals who have the disease have been revealed. Duplicate the counselors feat
A RFLP is discovered that is linked to the gene for Duchenne’s muscular dystrophy (DMD). DMD is an X-linked, recessive trait. The RFLP is 2 map units from the gene for DMD. Consider the following pedigree and Southern blot using a probe that hybridizes to the RFLP. Which band/s is/are associated with DMD? What is the genotype for individuals 3 and 4? (Remember, this is an X linked disease, so use X’s and Y’s to denote). Individual 9 married a man who does NOT have muscular dystrophy, and she is pregnant. DMD is an X-linked trait. What is the probability for their child to have DMD? An amniocentesis is performed and it is determined that 9’s child in utero has only a 10 kb band that hybridizes to the same probe used above. What can you say about the child now?
What is a molecular marker? Elaborate physical chromosome mapping with the help of molecular markers
Why is it more efficient to perform a test cross with a homozygous recessive donor than a homozygous dominant donor? How could the same information still be found with a homozygous dominant donor?
Refer to the sequence characteristics of the alleles for Gene A (A1 = Allele 1 and A2 = Allele 2) below: Question: What DNA marker system can be developed for Gene A as characterized above, for example to study A-allele diversity? Briefly describe your proposed DNA marker i.e. concept overview, type/frequency/site of DNA mutation, method of resolution, genetic inheritance, etc.
A genetic disorder is caused by a LOF mutation (Bm) and epigenetic imprinting of gene B. Through pedigree analysis of many families, researchers have observed the following results: Female carrier B+Bm x B+B+ --> B+Bm and Mother's genotype Father's genotype Children's genotype Children's phenotype Cross 1: B+Bm B+B+ B+Bm , B+B+ some affected, some unaffected Cross 2: B+B+ B+Bm B+Bm , B+B+ always unaffected Based on these results, gene B is imprinted on the: a. maternal b. paternal
The data set attached presents the results of a testcross using female flies heterozygous for three traits and male flies, which are homozygous recessive. For simplicity, mutant alleles are shown with letters a, b, and c and wildtype alleles are indicated by a “+” symbol. For this part of the report do the following in order: a) Determine the gene order (which gene is in the middle?)d) Construct a genetic map for the three genes, including the map distances between them. Clearly indicate the logic you followed and show all your calculations. Include the full distance calculations for the two most distanced genes (do not just add the other 2 distances). Ensure the work is neat and clear and does not contain spelling or grammatical errors so that it is understandable. Make sure to double check the solution provided.
For linkage analysis, a test cross is used rather than a hybrid cross. Why is this essential? Why would a hybrid cross result in incorrect estimates of genetic distance?
Two linked loci have a recombination frequency of 5%. A series of crosses is performed. The P generation includes an individual that is homozygous dominant for trait 1 and homozygous recessive for trait 2. The second individual is homozygous recessive for trait 1 and homozygous dominant for trait 2. The F1 generation is crossed with individuals that are homozygous recessive for both traits. If 400 F2 offspring are produced, how many offspring with each phenotype are expected? Fill in the table below with your answers. Phenotype Number of Offspring Predicted Recessive 1, Recessive 2 Dominant 1, Dominant 2 Recessive 1, Dominant 2 Dominant 1, Recessive 2 Total offspring 400 For the results above, determine which phenotypes are parental and which are recombinant. Phenotype Parental or Recombinant? Dominant 1, Dominant 2 Recessive 1, Dominant 2 Recessive 1, Recessive 2 Dominant 1, Recessive 2