Demyelination is the loss of myelin from neurones that are normally myelinated. Multiple sclerosis is a disease in which demyelination occurs in neurones involved in coordinating muscle movement.   Using your knowledge of nerve impulse generation and propagation, explain how nerve impulse generation and propagation would be affected in people who have multiple sclerosis. The explanation needs to be in the form of a step by step sequence of annotated drawings. This could be in the form of an annotated cartoon/picture strip. Compare this to nerve impulse generation and propagation in an individual who does not have multiple sclerosis.

Imagine that you decide to make a move. To make this decision, neurons in your brain's cerebral cortex (neuron A) fire nerve impulses that are sent to neurons in the spinal cord (neuron B). Neuron B then sends a signal to the muscle cells, causing them to contract, resulting in movement.a. In which part of the brain is neuron A located? and Explain your answer!b. Explain how the signal from neuron A is transmitted to neuron B and which part of the peripheral nervous system (PNS) is involved in this pathway!

When nerve cells contact each other, they form adherens junctions (AJs) at the point of contact. The main transmembrane (TM) protein in the junctions is N-cadherin. N-cadherin is a single pass TM protein with a short intracellular domain and a large extracellular domain on the amino end. Proper formation of the AJs requires both actin (MF) and microtubules (MTs). Motor proteins for MTs are dynein (-) end and kinesin (+) end (and were discovered by Michael Sheetz).  Maintenance of preformed AJs requires MFs . Adding drugs that disrupt MFs causes AJs to fall apart, and the N-cadherin is removed from the PM (by endocytosis). If the drugs are removed, MTs (& MFs) are required to restore the N-cadherin to the plasma membrane. choose answer for D1 and D2  D. Suppose cells contain a soluble kinase that modifies N-cadherin that has been removed from the PM. D-1. The kinase could catalyze modification(s) of the side chains of amino acids near (the N end) (the C end) (either end, but not…

Myelin sheaths function to electrically insulate neurons. Compare and contrast the myelination in the CNS and PNS (hint: include the cell types and their specific properties).