The image attached below depicts a histological slice of human cerebral cortex tissue. Using knowledge of the central nervous system and various cell-cell interactions, identify the key type(s) of cell junctions present in this image (for example, tight junctions, gap junctions, and adherens junctions/desmosomes). Briefly describe the function of these cell junctions. How would the function of the central nervous system be impaired if your above identified cell junctions were disrupted?

Assume a neuron is at rest and the following changes happen: Step 1: Neurotransmitter binds to an ionotropic excitatory neurotransmitter receptor causing an EPSP.  Step 2: With the neurotransmitter still bound either a NAM or non-competitive antagonist bind to the allosteric site of the receptor. Answer the following questions that explains how the NAM and non-competitive antagonist would differ in their actions.   4.) A. Going from step 1 to step 2 what would happen to the ionotropic receptor (ion channel) as a result of the NAM. B. Going from step 1 to step 2 what would happen to the ionotropic receptor (ion channel) as a result of the non-competitive antagonist.  C. Going from step 1 to step 2 how would membrane potential change as a result of the NAM D. Going from step 1 to step 2 how would the membrane potential change as a result of the non-competitive antagonist.

When nerve cells contact each other, they form adherens junctions (AJs) at the point of contact. The main transmembrane (TM) protein in the junctions is N-cadherin. N-cadherin is a single pass TM protein with a short intracellular domain and a large extracellular domain on the amino end. Proper formation of the AJs requires both actin (MF) and microtubules (MTs). Motor proteins for MTs are dynein (-) end and kinesin (+) end (and were discovered by Michael Sheetz).  Maintenance of preformed AJs requires MFs . Adding drugs that disrupt MFs causes AJs to fall apart, and the N-cadherin is removed from the PM (by endocytosis). If the drugs are removed, MTs (& MFs) are required to restore the N-cadherin to the plasma membrane. choose answer for D1 and D2  D. Suppose cells contain a soluble kinase that modifies N-cadherin that has been removed from the PM. D-1. The kinase could catalyze modification(s) of the side chains of amino acids near (the N end) (the C end) (either end, but not…

Two scientists calculated the membrane potential of a neuron using two different equations, the Nernst equation and the Goldman equation. Their calculations gave them slightly different predictions. What is the most likely reason for this difference? The lipid compositions of the cell membranes that the scientists studied were different. The scientists placed their measuring electrodes in slightly different positions. The temperatures of the fluid surrounding the cell membranes were different. The numbers of ions considered in the calculations were different. The scientists measured different numbers of cells.