d) Which amino acid(s) of the peptide are most plausible to be phosphorylated?e) Does the pl increase, decrease, or stay the same if all the possible amino acids you stated in youanswer for part (d) from the sequence are phosphorylated? Explain why. 3. Coronaviruses express a nucleocapsid protein that is needed for propagation, transcription, andassembly of the virus. The nucleocapsid protein must be phosphorylated by a kinase in the host cellto carry out these functions. One such kinase that has been recently reported is glycogen synthasekinase 3 or GSK-3. The following is the 10-letter sequence of the nucleocapsid protein that isrecognized and phosphorylated by GSK-3: SSRGTSPARM.Note: pk. N-terminus = 9.3; pk. R = 12.5; pK. T= 13; pK. S= 13; pK. C-terminus = 4.3a) What is the sequence of the peptide using the three-letter amino acid abbreviations?b) Draw the chemical structure of the peptide when it is at pH 8. Assign charges and label the peptidebonds.c) What is the pl of the peptide? Do not use an online resource to calculate this value. Show yourwork to receive credit.

The gene is the sequence of nucleotides that code for a specific protein. The proteins are the…

Answered: d) Which amino acid(s) of the peptide…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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1. Glycoproteins coat the outside of viruses; in particular they are important in helping HIV dock to our cells and also help the virus evade our immune system. Below is an image of the HIV transmembrane gp120 protein docking to human cd4 cells via the CXCR4 receptor. HIV-gp120 HIV CXCR4 Coreceptor CCR5 Coreceptor CD4 Receptor CD4 Cell a) i) Describe the general chemical interactions that might be involved in protein- protein interactions between the HIV gp120 protein and the human cd4 CXCR4 protein. Hypothesize what type of amino acid R groups you might find on the ii) exterior regions of each of these proteins, iii) and on the membrane bound portion of these proteins. b) The tertiary structure of gp120 is shown below. Please describe the protein (make sure to cover primary, secondary, and tertiary levels).
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A cell is infected with an HIV mutant that results in very little virus being released into the medium that is used to grow the cultured cells. Upon electron microscopy it is noted that the membrane of the infected cell is idenitcal in appearance to a cell that has not been infected. In addition there is relatively little viral RNA in the cells and relatively few proviruses in the cellular genome when compared to a non-mutant HIV infection. Which of the following proteins is most likely mutated? Multiple Choice gag reverse transcriptase vif vpu
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Researchers studying the SARS-CoV-2 virus, also known as COVID-19, have found that the virus is able to circumvent its host cell's normal defenses by leaving the cell via its lyso- somes rather than its normal secretory vesicles, as illustrated in the figure below. endoplasmic reticulum nucleus disrupted lysosomal functions Entry and egress of the SARS-CoV-2 virus A Golgi complex Which of the following best explains their findings? B lysosome (deacidified) С lysosome (acidified) B-coronavirus normal biosynthetic pathway egress via lysosomal trafficking SARS-CoV-2 inhibits lysosomes of its host cells by decreasing the pH within them. SARS-CoV-2 activates lysosomes of its host cells by decreasing the pH within them. SARS-CoV-2 activates lysosomes of its host cells by increasing the pH within them. D SARS-CoV-2 inhibits lysosomes of its host cells by increasing the pH within them.
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Viruses with negative sense RNA genomes typically, make proteins by: (Ignore retroviruses, and the unusual characteristics of coronaviruses) Translation of short RNA transcripts generated by RDRP Generating a DNA copy, which is then transcribed by host RNA polymerase. Translation of the viral genome by host ribosomes. Production of a polyprotein, which must be cleaved into smaller proteins. Generating a negative sense genome copy, which is then translated by host ribosomes.

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d) Which amino acid(s) of the peptide are most plausible to be phosphorylated? e) Does the pl increase, decrease, or stay the same if all the possible amino acids you stated in you answer for part (d) from the sequence are phosphorylated? Explain why.