Glutathione is an essential tripeptide in your body that helps minimize oxidative stress. Beginning with individually protected amino acids and any other reagents/solvents of your choosing, propose an efficient multi-step synthesis of glutathione using either a solution-phase or solid-phase peptide synthesis strategy. Please show intermediates after each synthetic step (peptide coupling, deprotection, etc), however, do not show any mechanistic details. Depict your peptide chains as bond-line structures after each intermediate and use the commonly accepted abbreviations for any selected protecting groups.
Glutathione is an essential tripeptide in your body that helps minimize oxidative stress. Beginning with individually protected amino acids and any other reagents/solvents of your choosing, propose an efficient multi-step synthesis of glutathione using either a solution-phase or solid-phase peptide synthesis strategy. Please show intermediates after each synthetic step (peptide coupling, deprotection, etc), however, do not show any mechanistic details. Depict your peptide chains as bond-line structures after each intermediate and use the commonly accepted abbreviations for any selected protecting groups.
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter18: Functional Derivatives Of Carboxylic Acids
Section18.8: Interconversion Of Functional Derivatives
Problem BQ: Several compounds have been found to inhibit -lactamase, and drugs based on these compounds can be...
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