Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Briefly discuss (referring to the images provided) why mutant 2 fails to produce functional protein. Note that none of the mRNA transcribed from this gene is of the expected size; some of the mRNA molecules produced are 223 nucleotides shorter than expected, whilst others are 47 nucleotides longer than expected.
CDNA sequence from gene A
>CDNA
АСАТTTGCTTтсTGACACAACТСTGТТСАСТAGCAACСТСАААСAGACACCАTGGTGCATCTGAСТССТGAGGAGA
AGTCTGCCGTTACTGCCCTGTGGGGCAAGGTGAACGTGGATGAAGTTGGTGGTGAGGCCCTGGGCAGGCTGCTGG
TGGTCTACCСТTGGACCCAGAGGTTCTTTGAGTCCTTTGGGGATCTGTССАСТССТGATGCTGTTATGGGCAACC
CTAAGGTGAAGGCTCATGGCAAGAAAGTGCTCGGTGCCTTTAGTGATGGCCTGGCTCACCTGGACAACCTCAAGG
GCACCTTTGCCACACTGAGTGAGCTGCACTGTGACAAGCTGCACGTGGATCCTGAGAACTTCAGGCTCCTGGGCA
ACGTGCTGGTCTGTGTGCTGGCCCATCАСТТTGGCAAAGAATTCACСССАССАGTGCAGGCTGCСТАТСАGAAAG
TGGTGGCTGGTGTGGCTAАTGCCCTGGСССАСААGTAТСАСТААGCТCGCTTTСТTGCTGTCCAAТТТСТАТТАА
AGGTTCCTTTGTTCCCTAAGTCCAACTACTAAACTGGGGGATATTATGAAGGGCCTTGAGCATCTGGATTCTGCC
ΤAAΤAAAAACAΤΤΤATTTTCATTGCAA
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Transcribed Image Text:CDNA sequence from gene A >CDNA АСАТTTGCTTтсTGACACAACТСTGТТСАСТAGCAACСТСАААСAGACACCАTGGTGCATCTGAСТССТGAGGAGA AGTCTGCCGTTACTGCCCTGTGGGGCAAGGTGAACGTGGATGAAGTTGGTGGTGAGGCCCTGGGCAGGCTGCTGG TGGTCTACCСТTGGACCCAGAGGTTCTTTGAGTCCTTTGGGGATCTGTССАСТССТGATGCTGTTATGGGCAACC CTAAGGTGAAGGCTCATGGCAAGAAAGTGCTCGGTGCCTTTAGTGATGGCCTGGCTCACCTGGACAACCTCAAGG GCACCTTTGCCACACTGAGTGAGCTGCACTGTGACAAGCTGCACGTGGATCCTGAGAACTTCAGGCTCCTGGGCA ACGTGCTGGTCTGTGTGCTGGCCCATCАСТТTGGCAAAGAATTCACСССАССАGTGCAGGCTGCСТАТСАGAAAG TGGTGGCTGGTGTGGCTAАTGCCCTGGСССАСААGTAТСАСТААGCТCGCTTTСТTGCTGTCCAAТТТСТАТТАА AGGTTCCTTTGTTCCCTAAGTCCAACTACTAAACTGGGGGATATTATGAAGGGCCTTGAGCATCTGGATTCTGCC ΤAAΤAAAAACAΤΤΤATTTTCATTGCAA
Chromosomal DNA sequence from gene A
>chromosomal
АСАТTTGCTТСTGACACAAСTGTGTTCACТAGCAACСТСАААСАGACAССАTGGTGCAТСТGАСТССТGAGGAGA
AGTCTGCCGТТАСTGCCСTGTGGGGCAAGGTGAACGTGGATGAAGTTGGTGGTGAGGCССTGGGCAGGTTGGTAT
САAGGTTACАAGACAGGTТТАAGGAGACСААТАGAAAСTGGGCATGTGGAGACAGAGAAGACTCTTGGGTTTCTG
АTAGGCACTGACTCТСТСТGCCТАТТGGTСТАТТТТСССАСССТТАGGСTGCTGGTGGТСТАСССТТGGACCCAG
AGGTTCTTTGAGTCCTTTGGGGATCTGTCСАСТССТGATтGCTGTTATGGGCAACCCTАAGGTGAAGGCТСАТGGC
AAGAAAGTGCTCGGTGCCТТTAGTGATGGCCTGGCTCАССTGGACAАССТСААGGGCACCTTTGCСАСАСТGAGТ
GAGCTGCACTGTGACAAGСTGCACGTGGATCCTGAGAАСТТСАGGGTGAGTCTATGGGACGCTTGATGTTTTCTТ
ТССССТТСТТTТСТАТGGТТАAGTTCATGTCATAGGAAGGGGATAAGTAACAGGGTАСAGTTTAGAATGGGAAAС
AGACGAATGATTGCATCAGTGTGGAAGTСТСAGGATCGTTTTAGTTТСТТТТАТТТGCTGTTCATААСААТТGTТ
TТСТТTTGTТТААТТСТТGCTTTCTTTTTTTTTСTТCТСCGCAATTТTТАСТАТТАТАСТТААТGССТТААСАТТ
GTGTATAACАААAGGAAAТАТСТСТGAGATACATTAAGTAACTTАAAAAAAAАСТТТАСАСAGTCTGCСТAGTAС
ΑΤTACΤΑΤΤTGGAATATATGTGΤGCTTAΤTTGCAΤΑΤ TCAΤAATCTCCCTACTTTATΤTTCTTΤ ΤATTTTAAT Τ
GATACΑΤAAT CAT TATACATAT ΤΤATGGGTTAAAGTGTAATGTTTΑΑΤΑΤGTGTACACATAT T GAC CAAATCAG
GGTAATTTT GCATTTGTAAΤΤΤTAΑAAAT GCTTTCTTCTTTTAΑΤΑTACTTTTTTGTTTATCTTATTTCTAATA
СТТТСССТААТСТСТТТСТТТСAGGGCAАТААТGATAСААТGTATСАTGCСТСТТТGCACCATTCТАААGAATAА
СAGTGATAAТТТСTGGGTТАAGGCAATAGCAATATСTСTGCАTАТАААТАТТТСТGCATATAAATTGТAАСТGAТ
GTAAGAGGTTТСАТАТТGСТААТАGCAGCTACAАТССAGCTАCСАTТСTGСTTТТАТТTТАTGGTTGGGATAAGG
СTGGATTATТСTGAGTCCАAGCTAGGCCСТТТTGCTААТСАТGTTCАТАССТСТТАТСТТССТСССАСAGCTCСТ
GGGCAACGTGCTGGTCTGTGTGCTGGCCCАТСАСТТТGGCAAAGAATTСАССССАССАGTGCAGGCTGCCTAТCА
GAAAGTGGTGGCTGGTGTGGCTAАТGCCCTGGCCCACAGTATCАСТАAGCTCGCTTTСТTGCTGTCCААТТТСТ
АТТААAGGTТССТТTGTTСССТААGTCСААСТАСТАААСTGGGGGAТАТТАТGAAGGGCCTTGAGCATСTGGATТ
CTGCCΤAΑΤΑΑΑAAACAΤTTATTTCAT TGCAA
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Transcribed Image Text:Chromosomal DNA sequence from gene A >chromosomal АСАТTTGCTТСTGACACAAСTGTGTTCACТAGCAACСТСАААСАGACAССАTGGTGCAТСТGАСТССТGAGGAGA AGTCTGCCGТТАСTGCCСTGTGGGGCAAGGTGAACGTGGATGAAGTTGGTGGTGAGGCССTGGGCAGGTTGGTAT САAGGTTACАAGACAGGTТТАAGGAGACСААТАGAAAСTGGGCATGTGGAGACAGAGAAGACTCTTGGGTTTCTG АTAGGCACTGACTCТСТСТGCCТАТТGGTСТАТТТТСССАСССТТАGGСTGCTGGTGGТСТАСССТТGGACCCAG AGGTTCTTTGAGTCCTTTGGGGATCTGTCСАСТССТGATтGCTGTTATGGGCAACCCTАAGGTGAAGGCТСАТGGC AAGAAAGTGCTCGGTGCCТТTAGTGATGGCCTGGCTCАССTGGACAАССТСААGGGCACCTTTGCСАСАСТGAGТ GAGCTGCACTGTGACAAGСTGCACGTGGATCCTGAGAАСТТСАGGGTGAGTCTATGGGACGCTTGATGTTTTCTТ ТССССТТСТТTТСТАТGGТТАAGTTCATGTCATAGGAAGGGGATAAGTAACAGGGTАСAGTTTAGAATGGGAAAС AGACGAATGATTGCATCAGTGTGGAAGTСТСAGGATCGTTTTAGTTТСТТТТАТТТGCTGTTCATААСААТТGTТ TТСТТTTGTТТААТТСТТGCTTTCTTTTTTTTTСTТCТСCGCAATTТTТАСТАТТАТАСТТААТGССТТААСАТТ GTGTATAACАААAGGAAAТАТСТСТGAGATACATTAAGTAACTTАAAAAAAAАСТТТАСАСAGTCTGCСТAGTAС ΑΤTACΤΑΤΤTGGAATATATGTGΤGCTTAΤTTGCAΤΑΤ TCAΤAATCTCCCTACTTTATΤTTCTTΤ ΤATTTTAAT Τ GATACΑΤAAT CAT TATACATAT ΤΤATGGGTTAAAGTGTAATGTTTΑΑΤΑΤGTGTACACATAT T GAC CAAATCAG GGTAATTTT GCATTTGTAAΤΤΤTAΑAAAT GCTTTCTTCTTTTAΑΤΑTACTTTTTTGTTTATCTTATTTCTAATA СТТТСССТААТСТСТТТСТТТСAGGGCAАТААТGATAСААТGTATСАTGCСТСТТТGCACCATTCТАААGAATAА СAGTGATAAТТТСTGGGTТАAGGCAATAGCAATATСTСTGCАTАТАААТАТТТСТGCATATAAATTGТAАСТGAТ GTAAGAGGTTТСАТАТТGСТААТАGCAGCTACAАТССAGCTАCСАTТСTGСTTТТАТТTТАTGGTTGGGATAAGG СTGGATTATТСTGAGTCCАAGCTAGGCCСТТТTGCTААТСАТGTTCАТАССТСТТАТСТТССТСССАСAGCTCСТ GGGCAACGTGCTGGTCTGTGTGCTGGCCCАТСАСТТТGGCAAAGAATTСАССССАССАGTGCAGGCTGCCTAТCА GAAAGTGGTGGCTGGTGTGGCTAАТGCCCTGGCCCACAGTATCАСТАAGCTCGCTTTСТTGCTGTCCААТТТСТ АТТААAGGTТССТТTGTTСССТААGTCСААСТАСТАААСTGGGGGAТАТТАТGAAGGGCCTTGAGCATСTGGATТ CTGCCΤAΑΤΑΑΑAAACAΤTTATTTCAT TGCAA
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