Answered: Besides being a general base, what's…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Besides being a general base, what's the other function of Asp in mechanism of HIV-1 aspartate protease shown in the figure.

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HIV-1 Aspartate Protease is a retropepsin enzyme i.e., retroviral aspartyl protease enzyme. Besides being a general base, Aspartyl Protease is involved with the hydrolysis in retroviruses (HIV) and hydrolysis is essential for the life-cycle of HIV. This protease cleaves the polyproteins which are newly synthesized and cleaves at nine cleavage sites for the production of protein components of an HIV virion. HIV Virion is the infectious form of this virus, without HIV Protease, HIV virion is uninfectious.

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