Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Besides being a general base, what's the other function of Asp in mechanism of HIV-1 aspartate protease shown in the figure.
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HIV-1 Aspartate Protease is a retropepsin enzyme i.e., retroviral aspartyl protease enzyme. Besides being a general base, Aspartyl Protease is involved with the hydrolysis in retroviruses (HIV) and hydrolysis is essential for the life-cycle of HIV. This protease cleaves the polyproteins which are newly synthesized and cleaves at nine cleavage sites for the production of protein components of an HIV virion. HIV Virion is the infectious form of this virus, without HIV Protease, HIV virion is uninfectious.
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