Based on your understanding of how glycine metabolism is associated with cancer cell proliferation, the following figure best illustrates which aspect specifically? CO2 aspartate formate N₁ glutamins glycine 8C formate Glycine contributes to the biosynthesis of purines, where it contributes two carbon atoms and a nitrogen atom as part of the purine ring structure Glycine is a component of glutathionine and plays a critical role as the main antioxidant molecule Glycine fuels heme biosynthesis in the mitochondria Glycine has critical role in the cell's balance of NADP+/NADPH ratios

Why does activation of the phosphorylated b form of glycogen synthase by high concentrations of glucose 6-phosphate make good biochemical sense? It ensures that glucose is saved when it is abundant and not being used to fuel energy metabolism. It ensures that excess fuel is stored in the most reduced and energy-rich form. It prevents glycogen from being synthesized at the same time as it is being broken down. It prevents the mobilization of glycogen when glucose is already abundant.

The phosphorylation and oxidative decarboxylation of oxaloacetate by inorganic phosphate (Pi) to make phosphoenolpyruvate and carbon dioxide is endergonic under intracellular conditions. It is characterized by this equation:   Oxaloacetate + Pi ←→ Phosphoenolpyruvate + H2O + CO2 ΔG’ = +24.6 kJ/mol   The synthesis of GTP from GDP and inorganic phosphate (Pi) in solution is endergonic under intracellular conditions, and it is characterized by this equation:   GDP + Pi ←→ GTP + H2O ΔG’ = +30.5 kJ/mol   Write a new net thermodynamically coupled reaction equation that describes the synthesis of phosphoenolpyruvate from oxaloacetate using the hydrolysis of GTP to power the reaction and calculate the new net ΔG’ of this reaction. Show all of your work.

For each of the following proteins describe how the protein function would be altered (or not) in the following scenarios: A receptor tyrosine kinase that always dimerizes even in the absence of ligand 3-ketoacyl-CoA transferase (SCOT) that is expressed in the liver. CPT1 that doesn’t have a malonyl binding site               4. acylCoA dehydrogenase with complex V inhibited