Using the figure below, determine the metabolic intermediate(s) directly produced from the carbon atoms of each of the following amino acids. Check all that apply for each part. alanine, cysteine, isoleucine, leucine, Part 1 of 2 Valine leucine, lysine, glycine, serine, pyruvate threonine, tryptophan threonine, tryptophan phenylalanine, tryptophan, tyrosine acetyl CoA acetoacetyl CoA (CH,COCH,COSCA) asparagine, aspartic acid oxaloacetate citrate malate isocitrate Citric acid cycle phenylalanine, tyrosine fumarate Part 2 of 2 Asparagine fumarate acetoacetyl CoA pyruvate oxaloacetate succinyl CoA a-ketoglutarate acetyl CoA None of the above fumarate acetoacetyl CoA pyruvate oxaloacetate succinyl CoA a-ketoglutarate acetyl CoA None of the above a-ketoglutarate arginine, glutamic acid, glutamine, histidine, proline K succinate succinyl CoA isoleucine, methionine, threonine, valine

ẞ-Calendic acid is an omega-6, conjugated fatty acid that is the all-trans isomer of a-calendic acid. HOOC—CH,CH, CH, CH,CH, CH, Part: 0/2 Part 1 of 2 H C=C H C-H H-C H C=C H CH₂ -CH2-CH2-CH2-CH₂ When this fatty acid is partially hydrogenated with one equivalent of H₂ in the presence of a Pd catalyst, a mixture of constitutional isomers is formed. Modify the given structure to draw one of these possible products.

Determine the amino acid sequence of Peptide A, which was obtained by hydrolyzing a larger peptide with trypsin, using the data below: Total hydrolysis of Peptide A produces (Ala2, Arg, Glu, Gly, Met, Pro2, Ser, Tyr). Sequential Edman degradation of Peptide A produces a derivative of Ala in the first cycle; a derivative of Serine in the second cycle; and a derivative of Proline in the third cycle. Cleavage of Peptide A with chymotrypsin yields two peptides: a tripeptide III containing Ala, Arg and Gly; and a heptapeptide IV containing Ala, Glu, Met, Pro2, Ser and Tyr. Edman treatment of tripeptide III generated a derivative of Alanine. Cleavage of Peptide A with cyanogen bromide (which cleaves peptides on the C-terminal side of Methionine) yields two pentapeptides labeled I and II. Total hydrolysis or peptide I indicate that it contains Ala, Arg, Gly, Pro and Tyr; pentapeptide II contains Ala, Glu, Met, Pro, and Ser.

Which of the following amino acids would you expect to find more often near the center of a folded globular protein? Which ones would you expect to find more often exposed to the outside? explain your answers. Ser, Ser-p (a Ser residue that is phosphorylated), Leu, Lys, Gln, His, Phe, Val, Ile, Met, Cys–S–S–Cys (two cysteines that are disulfide- bonded), and Glu. Where would you expect to find the most N-terminal amino acid and the most C-terminal amino acid?