Achondroplasia,is characterized by difficulty converting cartilage to bone and thus results in shortened limbs. This trait is autosomal dominant. (A = achondroplasia allele; a = average height allele.) A husband and wife both have achondroplasia. The couple have a total 12 living children: 6 boys and 6 girls.  The husband is colorblind, which is an X-linked recessive trait, and the wife believes there is a chance she is a carrier of colorblindness, since that trait runs in her family. One of the couple’s daughters and three of their sons are colorblind.  (Xc = colorblindness allele; XC = normal color vision allele.) a) Please list all of the different gametes that the husband can produce. b) Please list all of the different gametes that the wife can prod

Huntington disease (HD) is a genetic disorder that usually first appears in middle age and, over time, leads to involuntary movements, impaired speech, difficulty swallowing and speaking, and cognitive decline. There is no cure for HD, and affected individuals eventually die, usually after 10 to 15 years of progressively worsening symptoms. Huntington disease is inherited as an autosomal dominant disorder. Presymptomatic genetic testing for HD is available for people with a family history of the disease. Individuals who have a parent with HD have a 50% chance of inheriting the HD gene and eventually having HD. Some of these individuals want to know if they will eventually get the disease, and they undergo presymptomatic genetic testing. Others do not want to know, given that there is no cure or effective treatment for the disease. If you were at risk for HD, would you want to undergo genetic testing? What are some reasons for and against having a genetic test for HD?

Mary has hemophilia, an X-linked recessive trait. From which of the following individuals could Mary NOT have inherited a hemophilia allele? O Her father O Her father's mother O Her mother's mother O Her father's father O Her mother's father

Cystic fibrosis is determined by simple dominant-recessive inheritance, where the trait for cystic fibrosis is recessive. Given Rnormal, r is CF gene, complete the following Punnett square

hemophilia is a sex linked recessive disease.  Dick does not have hemophilia.  His wife Debi is a heterozygote. They are having fraternal twins, one of each sex, who they have named Dick Jr. and Debi Jr.  What are the chances of Dick Jr. having hemophilia?  Debi Jr.?

Hemophilia (reduced blood clotting) is an X-linked recessive disease in humans. A woman with hemophilia mates with a man who exhibits normal blood clotting. What is the probability that their child will have hemophilia?

Sheree is referred to a genetic counselor because a cystic fibrosis (CF) test done as a routine part of her prenatal care indicated that she is a carrier of the most common mutant allele. Sheree is stunned, because no one in her family has the disease. She is 26 years old. The genetic counselor would most likely explain autosomal recessive inheritance and suggest that Sheree's husband be tested for the CF allele. explain autosomal dominant inheritance and suggest that Sheree's husband be tested for the CF allele. explain autosomal recessive inheritance and suggest that Sheree's parents be tested for the CF allele. advise Sheree to have amniocentesis to check the fetus for the CF genotype.

Two brothers have thick hair that grows over their faces and most of their bodies. This human disorder, called Ambras Syndrome, shows x-linked dominant inheritance. The mother of the boys is also affected by Ambras Syndrome, although her excessive hair growth occurs in various, scattered patches on her skin rather than a continuous coverage like her sons. What is the most likely explanation for the patchy expression of hairlessness on the mother's skin? (2-3 sentences)

A man affected with HoHomania and a woman affected with HoHomania mate and have an unaffected son.  Which of the following mechanisms of inheritance can not be ruled out?  Choose all that can not be ruled out. Autosomal Dominant Autosomal Recessive Y-linked All of the mechanisms shown can be ruled out X-linked Recessive X-linked Dominant

Amelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is not expressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta  A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta Identify the parental genotypes.  Complete the Punnett square for the parental cross, and identify the…