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Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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
Transcribed Image Text:A. Cyclin Expression Cycle
1. What are the two factors involve in the illustration Cyclin Expression Cycle?
2. Identify the cyclin fluctuation in every stage of the cell cycle.
3. What do you think is the role of cyclin fluctuation at a given stage of a cell cycle?
Concentration
G₁ cyclin
G₁ Phase
Cyclin Expression Cycle
G₁/S cyclin
S Phase
S cyclin
M cyclin
G2 Phase M Phase
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- Aa v A A nt Paragraph Styles Nocodazole is a potent inhibitor of microtubule polymerization, which is required for formation of the mitotic spindle. By treating a population of mammalian cells with nocodazole for a time and then washing it out of the medium, we can synchronize the cell population. In the presence of nocodazole, where in the cell cycle do you expect the cells to accumulate? What mechanism do you think is responsible for stopping cell-cycle progression when cells are treated with nocodazole? D Focus COUarrow_forwardYou have isolated a temperature-sensitive cell-cycle mutant. The mutated gene encodes the activating subunit of the APC. The mutant protein is defective at high temperatures. You sort several thousand cells and recover the WT-looking profile below: Cells (in thousands) O G1 OM O G2 OS E 5 Next you grow the mutant at the restrictive high temperature and sort an equal number of cells. First, what phase of the cell cycle do you expect the cells to arrest in? 3 2 50 100 150 200⁰ 250 Propidium iodide fluorescence ♫ #tv A X MacBook Airarrow_forwardCan I get help constructing a concept map for the information provided below?arrow_forward
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