Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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a) What is the role of the Hox genes in animal development and what types of phenotypes do you see in mutations of Hox genes?
Provide an example of a mutant phenotype of a Hox gene in Drosophila. 3mrks
The Hox genes are known to act in combination. Panel A in figure below shows the normal expression patterns of the bithorax
complex, and segments that align with the expression patterns. Panel B shows the segmental phenotypes in mutants for both
abdominal - A and Abdominal - B, panel C shows the phenotypes in mutants for Abdominal - B, and panel D shows the phenotypes
in mutants for Ultrabithorax.
b) Describe how the segmental phenotypes illustrate the combinatorial action of Hox genes (you can ignore A9 as it is patterned by the
terminal patterning system). 4mrks
A) Parasegments
11 12 13 14
B)
D)
10 11 12 13 14
Segments
A2 A3 A4 A5
Abdominal-B
abdominal-A
Ultrabithorax
T1 12 13 A1
11 12 12 12 A2 A3 A4 A
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Transcribed Image Text:a) What is the role of the Hox genes in animal development and what types of phenotypes do you see in mutations of Hox genes? Provide an example of a mutant phenotype of a Hox gene in Drosophila. 3mrks The Hox genes are known to act in combination. Panel A in figure below shows the normal expression patterns of the bithorax complex, and segments that align with the expression patterns. Panel B shows the segmental phenotypes in mutants for both abdominal - A and Abdominal - B, panel C shows the phenotypes in mutants for Abdominal - B, and panel D shows the phenotypes in mutants for Ultrabithorax. b) Describe how the segmental phenotypes illustrate the combinatorial action of Hox genes (you can ignore A9 as it is patterned by the terminal patterning system). 4mrks A) Parasegments 11 12 13 14 B) D) 10 11 12 13 14 Segments A2 A3 A4 A5 Abdominal-B abdominal-A Ultrabithorax T1 12 13 A1 11 12 12 12 A2 A3 A4 A
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