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PLEASE ANSWER THE FOLLOWING LETTERS: a,b,c, and d
Examine the pedigree of the McGraw family shown below. Certain individuals in this family are affected by a brain condition that makes them more susceptible to vertigo. As a genetic counselor, you interview the family and draw DNA samples. You discover that the condition is caused by a mutation that changes the sequence 5’GCATTC3’ to 5’GAATTC3’ introducing an EcoRI cut site. You decide to amplify a 1200bp fragment from the DNA that spans this mutation and then digest it with EcoRI. You run the results on a gel next to a marker that shows bands at 2000bp, 1200bp, 900bp, 800bp, and 400bp. Some individuals from the pedigree are identified on the gel.
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- Lauren has chronic bronchitis and frequently ends up hospitalized with pneumonia. She has no family history of cystic fibrosis, a serious recessive genetic disorder which affects respiratory and digestive tracts. She and her husband Nat have one child after undergoing fertility treatments to overcome Nat's infertility. They are surprised when their child is diagnosed with cystic fibrosis and the genetic counselor tells them that they each also have the condition, which causes their bronchitis and infertility. Which of the following would be a reasonable explanation of their situation? Although the underlying disease is genetic, the severity of the disorder if influenced by environmental variation. Cystic fibrosis displays variable expressivity. There are different alleles of cystic fibrosis which cause differing forms of the disease. There are different alleles of cystic fibrosis which cause differing forms of the disease and Cystic fibrosis displays variable expressivity are the only…arrow_forwardHuntington disease (HD) can arise from a rare, short, in-frame addition of CAG nucleotide triplets within the huntingtin (HTT) gene coding region, which creates a disease-causing allele with the symptoms only appearing later in life. Using this information, describe an experiment that could be undertaken to determine whether a currently healthy young individual is a carrier of the HD-causing mutation. Describe the method you would use and how you would interpret the results of this experiment.arrow_forwardPlease help solve questions 9 and 10, thank you.arrow_forward
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