Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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PLEASE ANSWER THE FOLLOWING LETTERS: a,b,c, and d

Examine the pedigree of the McGraw family shown below.  Certain individuals in this family are affected by a brain condition that makes them more susceptible to vertigo.  As a genetic counselor, you interview the family and draw DNA samples.  You discover that the condition is caused by a mutation that changes the sequence 5’GCATTC3’ to 5’GAATTC3’ introducing an EcoRI cut site.  You decide to amplify a 1200bp fragment from the DNA that spans this mutation and then digest it with EcoRI.  You run the results on a gel next to a marker that shows bands at 2000bp, 1200bp, 900bp, 800bp, and 400bp.  Some individuals from the pedigree are identified on the gel.

A) Using all available information, what is the correct inheritance pattern of this
trait? Why?
B) Draw the pattern that would result for DNA amplification of individual I-2 in
the empty lane of the gel.
C) What is the probability if individual IV-1 mates with an affected male that
their offspring will be an affected
female?
D) What is the genotype of individual Il-2?
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Transcribed Image Text:A) Using all available information, what is the correct inheritance pattern of this trait? Why? B) Draw the pattern that would result for DNA amplification of individual I-2 in the empty lane of the gel. C) What is the probability if individual IV-1 mates with an affected male that their offspring will be an affected female? D) What is the genotype of individual Il-2?
MM
IV-1
IV-2
III-1
III-2
II-3
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Transcribed Image Text:MM IV-1 IV-2 III-1 III-2 II-3
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