A genetics counselor, Nashaly Montez, notices an odd pattern in Devin’s pedigree, a propensity for cancer development in his family at a higher incidence in males compared to females. This suggests to Nashaly an X-linked recessive disorder that is not manifesting in females as frequently compared to males who only have one X chromosome. She brings this to the attention of Devin’s primary health care provider who has his client checked for common cancer-causing mutations. A mutant LOF Fox3 regulatory allele is found that has an early NONSENSE codon that prevents protein expression. This is unfortunate, since in its wildtype form the protein is normally tumor-suppressing. 1) Nashaly, the genetics counselor, is doing academic research on Fox 3 gene expression in a genetically engineered bacterial strain transfected with recombinant DNA. By exposing the bacterium to increased heat, she induces a mutation in the ribosome and not the gene. Transcripts can bind to the mutant ribosome but translation soon halts and the uncharged stem of tRNA for initiator methionine never exits the ribosome. Where is the mutation in the ribosome? a Perhaps the A channel’s shape has been altered so the next amino acid can never be delivered, which halts translation. b Perhaps something is blocking the E channel so the uncharged tRNA methionine initiator stem is never allowed to leave, which halts translation. c Perhaps the peptidyl center of the ribosome is damaged and no longer functions to hook on the next amino acid, which halts translation. d All the answers could be correct.

Name: A genetics counselor, Nashaly Montez, notices an odd pattern in Devin’
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Description: A genetics counselor, Nashaly Montez, notices an odd pattern in Devin’s pedigree, a propensity for cancer development in his family at a higher incidence in males compared to females. This suggests to Nashaly an X-linked recessive disorder that is no

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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A genetics counselor, Nashaly Montez, notices an odd pattern in Devin’s pedigree, a propensity for cancer development in his family at a higher incidence in males compared to females. This suggests to Nashaly an X-linked recessive disorder that is not manifesting in females as frequently compared to males who only have one X chromosome. She brings this to the attention of Devin’s primary health care provider who has his client checked for common cancer-causing mutations. A mutant LOF Fox3 regulatory allele is found that has an early NONSENSE codon that prevents protein expression. This is unfortunate, since in its wildtype form the protein is normally tumor-suppressing.

Nashaly, the genetics counselor, is doing academic research on Fox 3 gene expression in a genetically engineered bacterial strain transfected with recombinant DNA. By exposing the bacterium to increased heat, she induces a mutation in the ribosome and not the gene. Transcripts can bind to the mutant ribosome but translation soon halts and the uncharged stem of tRNA for initiator methionine never exits the ribosome. Where is the mutation in the ribosome?

Perhaps the A channel’s shape has been altered so the next amino acid can never be delivered, which halts translation.

Perhaps something is blocking the E channel so the uncharged tRNA methionine initiator stem is never allowed to leave, which halts translation.

Perhaps the peptidyl center of the ribosome is damaged and no longer functions to hook on the next amino acid, which halts translation.

All the answers could be correct.

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