Concept explainers
A primitive eukaryote was discovered that displayed a unique
nucleic acid as its genetic material. Analysis revealed the following
observations:
(a) X-ray diffraction studies display a general pattern similar
to DNA, but with somewhat different dimensions and more
irregularity.
(b) A major hyperchromic shift is evident upon heating and
monitoring UV absorption at 260 nm.
(c) Base-composition analysis reveals four bases in the following
proportions:
Adenine = 8% Hypoxanthine = 18%
Guanine = 37% Xanthine = 37%
(d) About 75 percent of the sugars are deoxyribose, whereas
25 percent are ribose.
Attempt to solve the structure of this molecule by postulating a
model that is consistent with the foregoing observations.
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- For linear 34,000 kb DNA calculate a) contour length; b) the length of DNA as packaged in nucleosomes and c) the length of the DNA in a 30-nm fiber.arrow_forwardThe A and G compositions (mole percent) of one of the strands of a duplex DNA is A = 27 and G = 30. (a) What would be the T and C compositions of the complementary strand? (b) What can be said about the A and G compositions of its complementary strand?arrow_forwardAssume that the molar percentage of thymine in a double stranded DNA is 20. What are the percentages of the four bases (G, C, T, A)? b. The base content of a sample of DNA is as follows: A=31% G=31% T=19% C=19%. What conclusion can be drawn from this information?arrow_forward
- Draw the complete structure of the trinucleotide deoxyribo-oligonucleotide that is complementary to 5'dTdGdA3'. Draw this completely, showing all atoms of all parts of the structure.arrow_forwardpppApCpCpUpApGpApU-OH(a) Using the straight-chain sugar convention, write the structure of the DNA strand that encoded this short stretch of RNA.(b) Using the simplest convention for representing the DNA base sequence, write the structure of the nontemplate DNA strand.arrow_forwardAt 260 nm what component of DNA absorbs at this nm(hydrogen bond, phosphate backbone, nitrogenous base, deoxyribose).arrow_forward
- 1 10 5' АGT ССG A UGC 3' 8. There are inaccuracies in the DNA molecule shown here. || | | | | |||| 5 тCА GGCT АТG 3' a) Name three things that are wrong in the above DNA sequence. b) What type of chemical interaction is indicated by a "|" in the diagram? c) What happens to these interactions during DNA replication?arrow_forwardBriefly explain (1) the structure characteristics of DNA, (2) why different DNA molecules (i.e., with different sequences) could adopt the same B-form double helical structure, and (3) how certain proteins could recognize the specific sequences with the common B-form DNA.arrow_forwardDraw the structure of the standard Watson-Crick base-p airs involving the nucleotides dAMP,dGMP, dTMP, and dCMP. Clearly indicate the hydrogen bonds and show the structures as they wouldappear in th e double helix (Haworth projections for ribose).arrow_forward
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