A patient is hyperventilating. The "blowing off" of excessive carbon dioxide causes a decrease in blood H+ concentration. How can the carbonic acid buffering system function to correct this imbalance? CO2 + H20 > H2CO3 + H* + HCO3 O H2CO3 dissociates to form more H+ and raise pH. O HCO3- binds with H+ to form H2C03 and raise pH. O H2CO3 dissociates to form more H+ and lower pH. O HCO3- binds with H+ to form H2CO3 and lower pH. none of the above
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- Rebecca is found to have acidosis. She has elevated PCO2 and [HCO3-]. Which of the following is false? O her acidosis was caused from excess CO2 reacting with water to form carbonic acid O this is a metabolic acidosis kidney cells are using carbonic anhydrase to generate HCO3- for the blood O her blood pH is lower than normalWhich of the following is incorrect regarding the bicarbonate buffer system: A B C D an increase in proton will lower blood pH carbonic anhydrase catalyzes the formation of carbonic acid from proton and bicarbonate ion the purpose of the buffer system is to resist changes in blood pH alkalosis is defined as a pH of > 7.45Consider the equilibrium shown below; indicating the buffering system in the blood circulation. CO, + H,0 [H,CO3] HCO3¯+H* When a patient is choking, would this lead to an alkalosis or an acidosis situation? Explain.
- When travelling high altitude, one of the problem is alkalosis of the blood. Remember the equation for acid balance: CO2 + H2O ⇌ H2CO3 ⇌ HCO3− + H+ If there is a low amount of CO2 outside, then greater CO2 than normal will diffuse out of the lungs. This will cause the blood to become more basic. To counteract the problem, a drug may be taken to both lower the blood pressure and help correct the pH. To do this, it blocks a symporter of HCO3- and Na+ in the proximal tubule of the kidney. Q: How would blocking transport of HCO3- help to lower the pH of the blood?Muzolimine is a diuretic. Pure muzolimine (mp 127-129°C) is a crystalline solid at room temperature. Nifenazone is an analgesic. Pure nifenazone (mp 252-253°C) is a crystalline solid at room temperature. Which one of the following statement is correct? O A melting point of 212-217°C is consistent with a sample of nifenazone contaminated with a small quantity of muzolimine O A melting point of 212-217°C is not consistent with a sample of nifenazone contaminated with a small quantity of muzolimineA 58-year-old man with medical history of diabetes mellitus. Laboratory data showed pH=7.3, PaCO2=25mmHg, HCO3-=12mmol/L, fasting blood glucose=22mmol/L. This patient might have Metabolic alkalosis Metabolic acidosis Respiratory acidosis Respiratory alkalosis None of the above What happens in the above patient’s body to compensate for the current condition? Acid neutralises excess bicarbonate, and the lungs inhale CO2 as they hyperventilate Bicarbonate neutralises acid, and the lungs inhale CO2 as they hyperventilate Acid neutralises excess bicarbonate, and the lungs expire CO2 as they hyperventilate Bicarbonate neutralises acid, and the lungs expire CO2 as they hyperventilate Bicarbonate neutralises acid, and the lungs cannot compensate
- Carbonic anhydrase is an extremely efficient enzyme in red blood cells that performs the essential function of trapping C02 coming out of tissues and hydrating it with H,0. The product of this reaction is which dissociates into a proton and a (Hint: the reaction is H20 + CO2 +„H+ bicarbonate; carbonic acid carbonic acid; carbonate carbonate; carbonic acid carbonate; bicarbonate carbonic acid; bicarbonateIs this bicarbonate buffer system or respiratory system controls of acid-base bakance? Molecules react ro prevent drastic changes in H+ prevent concentration.Which statement BEST distinguishes metabolic acidosis from respiratory acidosis ? Metabolic acidosis occurs due to changes in blood glucose as opposed to changes in PO2 and PCO2 . Metabolic acidosis is a disturbance in blood pH caused by something other than an abnormal PCO2 . PCO 4s Metabolic acidosis occurs due to changes in PO2 as opposed to Metabolic acidosis occurs due to changes in bicarbonate as opposed to PCO2
- When dissolved in water a blank donates H+ and blank accepts H+Predict what will happen if a small amount of acid is added to the blood buffering system: H₂CO3 HCO3 + H+ The pH will go up from 7.4. The pH will be maintained because excess H* will be removed by the buffer. The pH will be maintained because more H* will be released by the buffer. The acid will increase the concentration of free hydroxide ions (OH-)How can I explain patient's pH value given his PaCO2 results in terms of that? Equation CO2 + H2O = H2CO3 = H+ + HCO3- Patient's results pH = 7.3 PaCO2 = 77 mm Hg HCO3- = 36 mEq/L