A given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population?   A1A1 = 30 A1A2  = 27 A2A2 = 12 A1A3 = 17 A2A3   = 10 A3A3 = 4 What would be the frequency of the A1A2 genotype? Assume the population is under Hardy-Weinberg equilibrium.   A. 0.03   B. 0.107   C. 0.27   D. 0.317   E. 0.09   F. 0.182

Some individuals in a canine population is susceptible to disease X, which strikes the adults. The susceptibility is later found to be determined by a single locus, with the R allele dominant over the r allele, such that the rr individuals are susceptible to the disease and the others immune. A population genetic survey showed that 1% of the newborns carry the rr genotype. Also, an independent estimation showed that mutation rate converting R to r is 5 × 10-3 per generation. You suspected that the r allele frequency is maintained by mutation- selection balance (MSB). If your hypothesis of MSB is true, then what is the survival rate for the rr adults? (Note: the equilibrium allele frequency ĝ is calculated as ĝ where %3D u is the mutation rate and s is the selection coefficient.) 5% 50% 95% 99% None of the above

Below in Figure 1 is a pedigree for a family afflicted by a genetic disorder. In some populations, Cystic fibrosis has an incidence of 1 in 2500 newborns. The carrier frequency calculated from this is 1/25. Analyze the pedigree below assuming the disease is similar to cystic fibrosis in incidence and carrier frequency. However this disease may not have the same type of genetic transmission as cystic fibrosis. What type of genetic transmission is most consistent with the pedigree? Label all the individuals that you can determine, with hypothesized genotypes. Label the individuals that have unknown genotypes with possible genotypes. Assuming her father is known to NOT be a carrier, calculate the probability that IV1 is a carrier for disease. Use the Χ2 test to determine whether your proposed transmission fits this data.

Police discovered the body of a woman who had been brutally assaulted. DNA from the crime scene was analysed and yielded the following SNP genotype: A1A2, G2G2, T1T2 for both the victim and a suspect. If the frequencies of A1, G1 and T1 alleles are 0.9, 0.99, 0.8 respectively, calculate the probability that another person in the group of suspects is responsible for the crime.

Suppose we define the Alzheimer’s disease phenotype as being diagnosed with the disease by age 75 years. In the human population, there are three alleles of the ApoE gene: ε2, ε3, ε4. They form an allelic series such that:   70% of 75 year olds with the ε4/ ε4 genotype have the Alzheimer’s phenotype 60% of 75 year olds with the ε3/ ε4 genotype have the Alzheimer’s phenotype 40% of 75 year olds with the ε3/ ε3 genotype have the Alzheimer’s phenotype 30% of 75 year olds with the ε2/ ε4 genotype have the Alzheimer’s phenotype 10% of 75 year olds with the ε2/ ε3 genotype have the Alzheimer’s phenotype   If I have the ε4/ ε4 genotype and my wife has the ε2/ ε3 genotype, what is the probability that our child will have Alzheimer’s by age 75. Explain your reasoning. [Can be answered in less than 75 words]

In a population, the dominant phenotype of a certain trait occurs 91% of the time. What is the frequency of the dominant allele?

Tay-Sachs disease is a recessive genetic disease. Individuals with this disease rarely survive past the age of four. In the general population, approximately 1 person in 300 carries the allele for this disease. However, in some populations, including the Irish Americans, the Ashkenazi Jews, and the Cajuns from Louisiana, the proportion of Tay-Sachs carriers is much higher (1 in 27 to 1 in 50) than in other populations. Such high frequency of an otherwise rare allele is expected when    Question 24 options:   populations experienced disruptive selection   populations were founded by a small number of settlers   the allele is advantageous at the heterozygous state    populations have higher than average mutation rates   populations experienced stabilizing selection

If the frequency of the aa genotype is 11%, what is the frequency of the AA genotype? Assume that there are only  two alleles  (i.e. a and A).

In humans, Rh-positive individuals have the Rh antigen on their red blood cells, while Rh-negative individuals do not. If the Rh-positive phenotype is produced by a dominant gene (A), and the Rh-negative phenotype is due to its recessive allele (a), what is the frequency of the Rh-positive allele if 84% of a population is Rh-positive?

If the frequency of the aa genotype is 19%, what is the frequency of the AA genotype? Assume that there are only two alleles (i.e. a and A).