A given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population?   A1A1 = 30 A1A2  = 27 A2A2 = 12 A1A3 = 17 A2A3   = 10 A3A3 = 4 What would be the frequency of the A1A3 genotype? Assume the population is under Hardy-Weinberg equilibrium.   A. 0.317   B. 0.182   C. 0.03   D. 0.09   E. 0.27   F. 0.107

Cystic fibrosis (CF), an autosomal recessive disease, occurs at a frequency of 1 / 2,500 people. What is the frequency of “carriers” for CF in the population?  SHOW YOUR WORK.

A given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population?   A1A1 = 30 A1A2  = 27 A2A2 = 12 A1A3 = 17 A2A3   = 10 A3A3 = 4 What would be the frequency of the A1A2 genotype? Assume the population is under Hardy-Weinberg equilibrium.   A. 0.03   B. 0.107   C. 0.27   D. 0.317   E. 0.09   F. 0.182

Consider the disease phenylketonuria (PKU), which is an autosomal recessive defect in the enzyme phenylalanine hydroxylase. The absence of the enzyme prevents phenylalanine from being metabolized causing unusually high levels of phenylalanine in the body leading to severe mental retardation. The selection coefficient for the recessive homozygous individuals is 0.7 and the frequency of the recessive allele in the population is 1.0 x 10-2.  If PKU is maintained by mutation-selection balance what is the predicted mutation rate?  The actual mutation rate is 1 X 10-4. What other mechanism might be affecting the allele frequency?

A population is made up of individuals where 77 have the A1A1 genotype, 65 have the A1 A2 genotype, and 123 have the A2A2 genotype. What is the allele frequency of A1? Answer to 2 decimal places.

In humans, people with at least one dominant RhD allele have a Rh positive blood type. People with a homozygous recessive genotype have a Rh negative blood type. In the United States, 85% of the population is Rh positive and 15% are Rh negative. What are the values of p and q for the population in the United States (assuming that the American population is at Hardy-Weinberg equilibrium)?

Albinism is due to a recessive allele of an autosomal gene. Let a represent the albino allele and A represent the normal non-albino allele. If one out of every 10,000 people were albino and assuming that the population is in Hardy-Weinberg equilibrium, A. what would be the phenotype frequencies of albino and non-albino ? B. what would be the allele frequencies of a and of A? C. what fraction of people can be expected to be of the genotype Aa? D. what fraction of people can be expected to be of the genotype AA?

If the frequency of PKU, an autosomal recessive disease, is 2.7% in males what is the frequency of females with PKU? ( You may assume that the population is in Hardy-Weinberg equilibrium.)

Consider an autosomal locus with alleles A and a. If the the allele frequencies are as follows Freq(A) = 0.4, Freq(a) = 0.6. , then what is the predicted frequency of heterozygous Aa individuals, assuming the population is in Hardy-Weinberg equilibrium? Freq(Aa) = ? Enter a number between 0 and 1, inclusive, for example 0.33