A couple has one child with bilateral retinoblastoma. The mother is free from cancer, but the father has unilateral retinoblastoma and he has a brother who has bilateral retinoblastoma. a. If the couple has another child, what is the probability that this next child will have retinoblastoma? b. If the next child has retinoblastoma, is it likely to be bilateral or unilateral? c. Explain why the father’s case of retinoblastoma is unilateral, whereas his son’s and brother’s cases are bilateral.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter16: Reproductive Technology, Genetic Testing, And Gene Therapy
Section: Chapter Questions
Problem 16QP: A couple has had a child born with neurofibromatosis. They come to your genetic counseling office...
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A couple has one child with bilateral retinoblastoma. The mother is
free from cancer, but the father has unilateral retinoblastoma and he
has a brother who has bilateral retinoblastoma.
a. If the couple has another child, what is the probability that this next
child will have retinoblastoma?
b. If the next child has retinoblastoma, is it likely to be bilateral or
unilateral?
c. Explain why the father’s case of retinoblastoma is unilateral, whereas
his son’s and brother’s cases are bilateral.

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