6. Look at the following pedigree for a given trait to answer the questions below. || 1 B A KEY: O I a) Is the allele for this trait found on the sex or autosomal chromosome? b) Is this a dominant or a recessive trait? c) Give the genotype of all the individuals unaffected male unaffected female male with trait = female with trait = = =
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- 1. The figure below shows a pedigree examining the presence of a genetic disorder across multiple generations of a family. Based off this figure, answer the following questions prompted: || IV 3 9 10 5 2 C 6 11 T 7 12 8 15 13 16 14 17 d) What is the genotype for individual #4 in this family pedigree? ||| c) Why are no family members identified as a carrier of this genetic disorder? Figure Key a) Using the figure key provided, identify which members of this family are affected by this genetic disorder in each generation. (Be sure to include sex and generation number for each individual identified). b) Is this an autosomal recessive, autosomal dominant, or sex-linked genetic disorder? Explain. Unaffected Female Unaffected Male Affected Female ||| Affected Male Female Carrier Male Carrier● Pedigree for a recessive disease I Signatures of a recessive trait: • Occurs rarely unless consanguineous. What can you infer about genotypes? ● = Cc || ||| IV VI VII What is the probability VII-2 be a carrier? A) 1/4 B) C) D) 1/3 E) 2/3 F) 1 1 сс Copyright © The McGraw-Hill Companies, Inc. Permission requir or 2 9999 3 9999 2 3 2 3 4 CC 51. In the pedigree below, Use "A" for the allele associated with the dominant phenotype, and lowercase "a" for the allele associated with the recessive phenotype. Determine what is the most likely mode of inheritance of this disease (whether it is inherited as the result of an autosomal dominant or autosomal recessive trait). Write the most probable genotype for each individual based on the mode of inheritance you have determined. Show how all the partners are crossed and the expected offspring produced (You may use Punnett Square) 1 dró || IV
- 1. Please consider the following pedigree. I 1 2 II 1 a) Assume that colour is controlled by a single sex-influenced gene where orange is expressed preferentially in females. Individuals I-1 and I-2 are homozygous for orange and blue respectively. Which individual/s in generation II will be blue? b) If colour is a controlled by cytoplasmic DNA, which individual/s in generation II will be orange?A young lady requested pre-marital genetic counselling because her sister had died in infancy of gangliosidosis, an autosomal recessive disease. What is the risk that this young lady has similarly affected offspring? What advice should be given?II. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked dominant and b) X-linked recessive in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xª, depending on mode of transmission of the disease respectively. *Unaffected/No carrier-Normal Unaffected X chromosome = X I || III 1 1 2 a) X-linked recessive 9 III 6 genotype (circle one): XX * 1 2 3 11x12 4 ΧΑΧΑ 2 5 xaxa *4 6 7 8 b) X-linked dominant 11 x 12 오 XAX хах
- 1. Please consider the following pedigree. I 1 II 1 a) Assume that colour is controlled by a single sex-influenced gene where green is expressed preferentially in males. Individuals I-1 and I-2 are homozygous for red and green respectively. Which individual/s in generation II will be red? b) If colour is a controlled by cytoplasmic DNA, which individual/s in generation II will be green?6) For the pedigree shown below, answer the following questions. I II III a) What type of inheritance is shown? Explain how you know. b) The genotype of individual I -2 is The genotype of individual II -1 isDuchenne muscular dystrophy is an X-linked, recessive disorder in which muscles waste away early in life, resulting in death in the teens or twenties. A man and woman in their late thirties have five children—three boys (ages 1, 3, and 10 years) and two girls (ages 5 and 7 years). The oldest, boy shows symptoms of the disease. What are the probabilities that their other children will develop the disease? Give only typing answer with explanation and conclusion
- Given these parents-note, they are NOT quite the same as each other!: mom = Aa Bb Cc Dd dad = Aa Bb cc Dd NOTE that the A gene acts incompletely dominantly. a) What chance does their baby having the "strongest phenotype" in A, being recessive in b, recessive in c, and dominant in D? Give one fraction. Show work. b) phenotype? Now assume mom was CC instead of Cc. Now what is the chance of having that sameConsider a couple: a woman who is homozygous for a recessive mutation that causes X-linked colorblindness, and a man with full color vision (he does not carry a copy of the mutation). a) What is the probability that a son of this couple will be colorblind? b) What is the probability that a daughter of the couple will be colorblind?re ||| E 6. Label the genotypes for this pedigree of an X-linked recessive disorder (red- green colorblindness). (a) 2 2 3 1 3 a. How do you know? b. Label the genotypes. 4 O To 2 4 5 5 6 6 7. Is the following pedigree autosomal recessive, autosomal dominant or X-linked recessive? 2 8 O T 58