5. Consider the decarboxylation of dimethyloxaloacetate 7 to 3-methyl-2-oxobutyrate 8 shown below H3CO cat. Cu²+ & CO2 CH3OH (aq) cat. Cu²+ no reaction CH3OH (aq) 9 a. Provide a mechanism to account for the fact that Cu2+ catalyzes this reaction. b. In one sentence explain why Cu2+ does not similarly catalyze the decarboxylation of 9.

5. Consider the decarboxylation of dimethyloxaloacetate 7 to 3-methyl-2-oxobutyrate 8 shown below H3CO cat. Cu²+ & CO2 CH3OH (aq) cat. Cu²+ no reaction CH3OH (aq) 9 a. Provide a mechanism to account for the fact that Cu2+ catalyzes this reaction. b. In one sentence explain why Cu2+ does not similarly catalyze the decarboxylation of 9.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway

Section: Chapter Questions

Problem 11P: Understanding the Mechanisms of Reactions Related to Transketolase The mechanistic chemistry of the...

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5.1
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