Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Transcribed Image Text:38. Adenosine deaminase acting on RNA
(ADARS) catalyzes the conversion of
Adenosine to Inosine (at right). This is an
RNA editing enzyme. Why does A to I
editing destabilize duplex RNA? Draw out
how inosine could base pair with cytosine
(Draw hydrogen bonds as dashed lines,
and draw hydrogen atoms involved in
hydrogen bonds. Indicate the position of the ribose with an "R" (you do not need to draw
the ribose).
ADAR
NH2 Editing
N-
enzyme
N-
NH
N.
N.
N.
RNA
RNA
Adenosine
Inosine
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