3. After an IV bolus dose of 500 mg of a drug, the following data were collected: (first order elimination) Time (hrs) Cp (mcg/ml) 1 64 2 3 48 34 Determine the following: a) Co b) Rate constant c) Half-life 4 25 6 8 10 14 7.8 4.2

3. After an IV bolus dose of 500 mg of a drug, the following data were collected: (first order elimination) Time (hrs) Cp (mcg/ml) 1 64 2 3 48 34 Determine the following: a) Co b) Rate constant c) Half-life 4 25 6 8 10 14 7.8 4.2

Appl Of Ms Excel In Analytical Chemistry

2nd Edition

ISBN:9781285686691

Author:Crouch

Publisher:Crouch

Chapter13: Kinetic Methods

Section: Chapter Questions

Problem 2P

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Question

Please solve using these equations:

dCp/dt=-k(Cp)

t1/2= 0.693/k

Cp=C0e^-k(t)

3. After an IV bolus dose of 500 mg of a drug, the following data were collected:
(first order elimination)
Time (hrs)
Cp (mcg/ml)
1
64 48 34
2 3 4
25
Determine the following:
a) Co
b) Rate constant
c) Half-life
d) Total area under the curve
6
14
8
7.8
10
4.2

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