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- One type of diuretic given to people with high blood pressure, renal disease and congestive heart failure are thiazide-type diuretics. These drugs inhibit sodium ion reabsorption by inhibiting the transport in the ascending limb of the loop of Henle. A) What does it mean to inhibit the transport of sodium ions in the loop of Henle? B) Explain how this inhibition of sodium ions in the loop of Henle could help increase urine production.Renal Physiology (humans) a) When blood pressure declines, granular cells produce renin, an enzyme that enters the circulatory system and cleaves angiotensinogen. b) Aldosterone acts on cells of the collecting duct to cause both sodium reabsorption into blood and potassium secretion into urine. c) The production of excess aldosterone by an adrenal tumor would indirectly lead to the hyperpolarization of excitable cardiac cells. d) Both (a) and (b) are correct and (c) is incorrect e) Statements (a), (b) and (c) are all correctGiven: A patient’s GFR (glomerular filtration rate) is 125 ml/min, and his urine is produced at a rate of 1.25 ml/min. (A) By what factor is the inulin concentrate in his urine. (B) The concentration of glucose in his plasma is 5 mmol/l. His renal reabsorption of glucose is completely inhibited. What would be the concentration of glucose in his urine? (answer parts a and b)
- a. A person ingests an ion-channel inhibitor, such that the ion channels present in the Loop of Henle are only able to pump at half their normal rate? b. What would this person notice about changes to their physiological filtration? (Answer a and b)1.8 Which of the following is likely to cause the kidney to change the reabsorption of water and/or NaCl? Select one: a. Drinking 1 L of water in a short period of time. (Assume that you weren't dehydrated.) b. Eating a big bag of salty potato chips. c. Forgetting to drink water all day. d. Exercising vigorously in a very hot environment. e. All of the aboveA. Maintenance of fluid balance is important for the survival of humans. How does antidiuretic hormone and aldosterone contributes to the maintenance of fluid balance?(ii) High blood pressure can result from increased sodium concentration of plasma. What is the main hormone involved in regulation of sodium and how does it affect the sodium content of blood?(iii) Compare intracellular fluid to extracellular fluid in terms of their chemical composition of proteins, sodium and potassium.(b) Explain the morphological changes that will occur and the driving force when red blood cells are place in (i) 2.0 % sodium chloride solution (ii) 0.9 % sodium chloride solution (iii) 0.01 % sodium chloride solution 1. What are the 4 causes of subarachnoid hemorrhage? 2. State the factors involved in congenital berry or saccular aneurysm 3. Mention 5 specific brain tumors that you know. 4. What is dura mater, arachnoid matter and pia matter? 5. What is meningioma 6. What is acute subdural hematoma 7.…
- 50. During an in vitro experiment studying aldosterone secretion, an isolated adrenal gland is perfused with various concentrations of potassium and angiotensin II. Which of the following combinations of potassium and angiotensin II will cause the greatest increase in aldosterone secretion? Angiotensin II Į ( A) B) C) D) E) F) G) H) 1) Potassium Increased Increased Increased Normal Normal Normal Decreased Decreased Decreased increased unchanged decreased increased unchanged decreased increased unchanged decreased6) Patrick's urine sample reveals a high concentration of glucose. Is glucose normally present in urine? Suggest two possible mechanisms to explain why the kidney would excrete excess glucose, and what abnormality may underlie those conditions.(a) Identify the two reactions that allow the kidney to produce NH4+. (b) Which gluconeogenic precursor is thereby generated? Describe thepathway by which it can be converted to glucose.
- 1. There is a medical condition called Syndrome of Inappropriate Anti-Diuretic Hormone (SIADH) secretion, which can occur as a result of head trauma. Patients with this condition retain water and present with a volume imbalance. A) Name the type of volume imbalance and accompanying direction of changes in ICF and ECF volumes and osmolality. B) Calculate the changes in osmolality and volumes of extracellular and intracellular fluid compartments if 3 liters of water are retained by a patient with SIADH. You can assume that the patient’s initial volumes were ECF=14 L, ICF=28 L. And his initial body osmolality = 290 mOsM. Remember that the total solute in the ICF compartment is kept in place by the cell membrane barrier.50. During an in vitro experiment studying aldosterone secretion, an isolated adrenal gland is perfused with various concentrations of potassium and angiotensin II. Which of the following combinations of potassium and angiotensin II will cause the greatest increase in aldosterone secretion? Angiotensin II A) B) C) D) E) F) G) 1) Potassium Increased Increased Increased Normal Normal Normal Decreased Decreased Decreased increased unchanged decreased increased unchanged decreased increased unchanged decreasedThe Na+-glucose transporters SGLT2 and SGLT1 are located at different levels of the kidney proximal tubule to minimize spillover of the glucose into the urine (See diagram attached) a) Consider the Na+-glucose coupling ratios for SGLT2 and SGLT1. Why would localization of SGLT2 in the early proximal tubule and SGLT1 in the late proximal tubule be advantageous? b) The Michaelis constant (Km) for the SGLT2 and SGLT1 transporters are 2 mM and 0.5 mM, respectively. Is SGLT2 or SGLT1 the higher affinity Na+-glucose transporter? d) Dapagliflozin is an SGLT1 inhibitor and commonly prescribed to treat type 2 diabetes. Why would this be of benefit to a diabetes patient?