Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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- factors responsible for a negative resting membrane potential include: check all that apply: a. Na K pump b. different carrier proteins c. uneven distribution of ions d. difference in permeability of ions e. high potassium concentration in ECFarrow_forwardQ1. A loss-of-function mutation in the ion channel responsible for thegeneration of end-plate potentials results in a diminished permeabilityof the ion channel.a) What are the likely functional consequences of this mutation? Theanswer should provide a detailed description of the processes that arelikely to be affected.arrow_forward1.A poison causes a drastic rise inE value with stimulation of the membrane.Thereafter membrane is slow to return towards resting membrane potential and levels off several millivolts above the threshold potential. This poison has likely affect which feature of the membrane? a) voltage gated na+ channels. b) voltage gated K+ channels. c) Na+/K+ Atp pump 2. All cell membrane demonstrate action potential if stimulated enough? True/False. 3. how many peaks are there in a compound action potential? a)2. b)4 c)6 d)8 4. Increasing the ionic concentration in the salt bridge results in E value increase to a point after which it plateeus. This is evidence brownian movement at work in the ionic solution that is keeping from energy flowing through the bridge with the fidelity that is seen in the metal bridge? True/ False 5. All cell membrane demonstrate action potential if stimulated enough? True or False.arrow_forward
- Calculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50 M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane equally permeable to both ions.arrow_forwardExplain what is going on at sites A, B, C, D, F and G in relation to CHARGE (negative, positive, rising, falling) and open or closed Na+ and K+ ion channels +40 Voltage (mv) O -55 -70 Threshold B A 1 E D 2 3 Time (ms) F 4 Garrow_forward13) Draw a graph representing the changes in membrane potential across the axonal membrane before, during, and after an action potential. On your graph, use a highlighter to clearly indicate for which portions of your graph the letter corresponding to each cellular event listed below belongs. List of cellular events: A) All K* channels open B) All Na* channels close C) The Na*/K* ATPase cotransporter transports Na* and K* across the membrane. D) All Na* channels open E) The threshold value of membrane potential is attained. F) All K* channels close G) Some Na* channels open Your graph:arrow_forward
- If: membrane potential=-70mV, ENa=+60mV, and Ex=-90mV, consider which directions Na+ and K+ will leak across the membrane. If both ions are crossing the membrane, what is the most important factor in determining whether membrane potential will become more positive or more negative?arrow_forwardA True OUTSIDE CELL This cell is at rest. False INSIDE CELL C D T Earrow_forwardThe negatively charged intracellular environment and resulting resting membranepotential of neurons and muscle cells fundamentally develops because of:A. the presence of a high extracellular potassium concentration.B. the presence of negatively charged intracellular proteins.C. the high electron concentration found in the extracellular fluidsD. the presence of voltage-gated-sodium channellsarrow_forward
- For the ion concentrations in Table 12.1, calculate the equilibriumpotentials for each ion species in squid axons and in mammalianmuscle fibers.arrow_forwardThe resting membrane potential…A) Can be approximated using the Nernst equation.B) Is established by a difference in charges across the cell membrane, with the inside more positive than the outside.C) Has no influence on the driving force for flow of a particular ion across the cell membrane.D) Is more dependent on the passive flow of potassium vs. sodium ions through leak channels across the cell membrane.E) Stays the same during an action potential.arrow_forwardSeparately, draw a table using arrows to depict the appropriate magnitude and direction of the forces and ion fluxes at different membrane potentials for a ligand-gated channel that is equally permeable to both ion X+ and ion Y+. The equilibrium potential for ion X+ is -60 mV, and the equilibrium potential for ion Y+ is -20 mV. Which item best represents the forces and fluxes for a membrane potential of -40 mV?arrow_forward
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