7. Given the following concentrations:K*ICF 140 mMNaCH12 mM12 mMECF3 mM 145 mM 120 mMa) Calculate the equilibrium potentials of K, Na* and Cl using the Nernst equation.EK =ENa =ECi =b) In the case above, if the membrane is permeable onlyto K, what would be the predicted membrane potential?c) If the membrane is equally permeable to K and Na",and impermeable to all other ions, what would be thepredicted membrane potential?

Given; [K+]i = 140 mM [K+]o = 3 mM [Na+]i = 12 mM [Na+]o = 145 mM [Cl-]i = 12 mM [Cl-]o = 120 mM

Answered: . Given the following concentrations:…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Assume that in a neuron, the plasma membrane permeability values for potassium (K+), sodium (Na+), and Cl− are the following: PK = 1, PNa = 12, and PCl = 0.5. Based on physiological concentrations of K+, Na+, and Cl− (refer to the table), determine the membrane potential in this neuron.
factors responsible for a negative resting membrane potential include: check all that apply: a. Na K pump b. different carrier proteins c. uneven distribution of ions d. difference in permeability of ions e. high potassium concentration in ECF
Q1. A loss-of-function mutation in the ion channel responsible for thegeneration of end-plate potentials results in a diminished permeabilityof the ion channel.a) What are the likely functional consequences of this mutation? Theanswer should provide a detailed description of the processes that arelikely to be affected.
Explain action potential generation in terms of cell potential, ionic concentrations, movement of ions across the membrane, gates, etc.
1.A poison causes a drastic rise inE value with stimulation of the membrane.Thereafter membrane is slow to return towards resting membrane potential and levels off several millivolts above the threshold potential. This poison has likely affect which feature of the membrane? a) voltage gated na+ channels. b) voltage gated K+ channels. c) Na+/K+ Atp pump 2. All cell membrane demonstrate action potential if stimulated enough? True/False. 3. how many peaks are there in a compound action potential? a)2. b)4 c)6 d)8 4. Increasing the ionic concentration in the salt bridge results in E value increase to a point after which it plateeus. This is evidence brownian movement at work in the ionic solution that is keeping from energy flowing through the bridge with the fidelity that is seen in the metal bridge? True/ False 5. All cell membrane demonstrate action potential if stimulated enough? True or False.
Calculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50 M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane equally permeable to both ions.
Explain what is going on at sites A, B, C, D, F and G in relation to CHARGE (negative, positive, rising, falling) and open or closed Na+ and K+ ion channels +40 Voltage (mv) O -55 -70 Threshold B A 1 E D 2 3 Time (ms) F 4 G
13) Draw a graph representing the changes in membrane potential across the axonal membrane before, during, and after an action potential. On your graph, use a highlighter to clearly indicate for which portions of your graph the letter corresponding to each cellular event listed below belongs. List of cellular events: A) All K* channels open B) All Na* channels close C) The Na*/K* ATPase cotransporter transports Na* and K* across the membrane. D) All Na* channels open E) The threshold value of membrane potential is attained. F) All K* channels close G) Some Na* channels open Your graph:
If: membrane potential=-70mV, ENa=+60mV, and Ex=-90mV, consider which directions Na+ and K+ will leak across the membrane. If both ions are crossing the membrane, what is the most important factor in determining whether membrane potential will become more positive or more negative?
List the Forces influencing sodium and potassium ions at the resting membrane potential?
A True OUTSIDE CELL This cell is at rest. False INSIDE CELL C D T E
The negatively charged intracellular environment and resulting resting membranepotential of neurons and muscle cells fundamentally develops because of:A. the presence of a high extracellular potassium concentration.B. the presence of negatively charged intracellular proteins.C. the high electron concentration found in the extracellular fluidsD. the presence of voltage-gated-sodium channells

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