About 12,820 new cases of invasive cervical cancer will be diagnosed in America every year (5). This is out of the 1,685,210 people diagnosed with cancer every year. About 39.6% of the US population will contract cancer in their lifetime (10). With so many people affected by cancer, it is beneficial to understand how cancer works. However, cancer is a very complex disease that scientists are still trying to understand themselves. Moreover, cancer can be a very frightening disease because of its difficulty to treat, and its lethality. Understanding the pathology and history of cancer can be beneficial to help understand the inevitable cancer diagnosis of yourself or a loved one.
First and foremost, cancer comes from changes in the genetic
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When you change the genetic makeup of a cell, you change the way it functions. When you change the genetic code for cell cycle regulation, you can develop cancer.
Common features among all types of cancer are metastasis, redirecting blood flow, unregulated cell proliferation, genomic instability and hiding from the immune system. The most dangerous aspect of cancer is that the disease can turn metastatic. 90% of cancer deaths come from metastasis (13). Metastasis is when somatic cells of the body have mutations in the genes that control cell placement. For example, if someone develops lung cancer, several cells in the tumor may leave the lung because the regulatory proteins that keep cells in place are no longer being made. This cluster of cells can travel to any part of the body and start to make tumors there. This is why someone can have lung cancer, but have tumors in their brain. In addition, tumors redirect blood flow so the cancerous cell population can stay alive. Furthermore, unregulated cell proliferation is when cancer cells divide despite signals to stop, and this is what causes tumors. Additionally, genomic instability is when your genes are in the wrong order in your genome. Your genome is all of your genes put together. If you think of a gene as an instruction to build a car part, the genome is the instruction manual to build the car. In cancer, cells have faulty instructions for cell
Cervical cancer is when there are malignant cells present in the cervix; it is developed in the lining of the cervix. A cervix is a narrow opening located at the bottom of the uterus that leads into the vagina. Cervical cancer mostly affects women between the ages of 40 and 55. This cancer can be prevented by screening for precancerous cells, and it can also be cured if it is detected at an early stage. Over the past few decades the number of cervical cancer cases has declined dramatically due to a more widespread screening of the disease. Today, it is estimated that 10,000 new
In the United States, it is one of the eight-most common cancer of women. According to researches, the data shows that Hispanic women are significantly more likely to be diagnosed with cervical cancer than the general population and their median age at diagnosis is 48. In 1998, about 12,800 women were diagnosed in the US and about 4,800 died. Among cancers of the female reproductive tract, it is less common than endometrial cancer and ovarian cancer. The rates of new cases in the United States was 7 per 100,000 women in 2004. Cervical cancer deaths decreased by approximately 74% in the
Almost all cervical carcinomas are caused by Human papillomavirus (HPV). Cervical cancer can be a life-threating disease. However, over recent years the occurrence of cervical cancer has declined as well as the chance of dying from it. A huge contributing factor to this decline is the importance of a regular pap smear. A pap smear can find cervical pre-cancer before it turns into cancer. Recently, a vaccine for HPV, has been on the market, which provides close to a 100% protection against pre-cancer and general warts. HPV and cervical cancer are two disease that are closely related. However, each disease effects not only similar populations, but also different populations, as well as having its own signs and symptoms, detection procedures,
Did you know there is more of a link between cervical cancer and HPV than smoking and lung cancer? Cervical cancer is currently the fourth most common cancer in women and the second leading cause of death from cancer in women. Along with those statistics, human papillomavirus is the most common sexually transmitted viral disease amongst men and women worldwide. The prevalence of women having a strain of HPV that ultimately leads to or increases the chance of cervical cancer is highly relatable. What is pathophysiology, signs, symptoms, prevention, and treatments of this ailment? You might ask will be covered in the next few pages of this paper.
At the age of 22, I found out that I had cervical tumors. My mother had asked the doctor if there was anyways I could ever have a baby, in the future. His answer, very unlikely. A week later, I went to the doctor’s office to get blood work and to get ready for my surgery. I was getting the tumors removed. Two days later, I was told I could not get the procedure done. I was pregnant. Very excited and shocked, hung up the phone and drove to my boyfriend at the times house to tell him the news. After four months of excitement. He told me he was getting to attach to the baby and left us both. About two months later, I meet a guy. He was nice, funny and was willing to take on the responsibly of being a father. We got married a few months later.
The fourth most common cancer in women worldwide happens to be Cervical Cancer. It also has the fourth highest mortality rate among cancers in women.
Cervical cancer has a major impact on women’s lives; it is the second most common cause of cancer-related diseases and death among women worldwide. According to the Center for Disease Control and Prevention (2010), cervical cancer is the cancer that forms in tissues of the cervix. The cervix is the lower, narrow end of the uterus that connects the vagina to the upper part of the uterus. Cervical cancer is a slow-growing cancer that may not cause any symptoms at first but may cause pelvic pain or bleeding from the vagina later. It is mostly caused by a human papillomavirus (HPV) infection. HPV is a common virus that is passed from one person to another during sexual activity (Center for Disease Control and Prevention [CDC], 2010).
Did you know there is more of a link between cervical cancer and HPV than smoking and lung cancer? Cervical cancer is currently the fourth most common cancer in women and the second leading cause of death from cancer in women. Along with those statistics, human papillomavirus is the most common sexually transmitted viral disease amongst men and women worldwide. The prevalence of women having a strain of HPV that ultimately leads to or increases the chance of cervical cancer is highly relatable. What is pathophysiology, signs, symptoms, prevention, and treatments of this ailment? You might ask will be covered in the next few pages of this paper.
According to the Centers for Disease Control and Prevention (CDC), Human papillomavirus (HPV) infects roughly 20 million individuals in the United States with 6.1 million new cases each year. There is no cure for HPV, only treatment for associated health problems. There are more than 30 strains of HPV that affect more than half of sexually active individuals in their lifetime. Public health risks involve several types of HPV leading to precancerous lesions and causing 70% of cervical cancer. Cervical cancer, the second most common cancer, affects many women globally. In the United States, nearly 10,000 women are diagnosed with cervical cancer annually and 3,700 of those women die. It has been reported by American Cancer Society that with early
There is a lot that can be done to decrease the chances of having cervical cancer. Also, having tests done by a health care provider can possibly help find changes that usually tend to go undetected. This may lead to finding the cervical cancer in the early stages. Lifestyle changes in addition to practicing safe sex may also help lower the chances of getting cervical cancer. Practicing safer sex can help reduce the risk of getting human papilloma virus which could lead to cervical cancer.
Cervical Cancer Early Detection Program Journal of Women’s Health 20(10):1479-84 doi: 10.1089/jwh.2010.2530. Epub 2011 Jul 20
In fact, early-detected cervical cancer can be highly cured. Howevers unfortunately, the second line treatment for the patient who suffers the recurrence or advanced stage of cervical cancer is limited. Today, the most up-to-date drugs for recurrent or advanced cervical cancer patient are only paclitaxel and cisplatin [2]. Surgery is only applicable for patients who are medically operable while radiotherapy and chemotherapy are inefficient in treating patients who build resistance to both treatments in a quick manner [3, 4]. Considering the limited treatment for the patient with advanced or recurrent cervical cancer, our previous project have revealed a new target therapy study by utilizing two dimensional (2D) cell culture assay. We
According to the Centers for Disease Control and Prevention (CDC), the leading cause of cervical cancer remains Human papillomavirus (HPV), a virus that passes from one person to another during sex.” (Centers for Disease Control and Prevention, 2015) . Although HPV is a common Sexually Transmitted Disease (STD), physicians suggest that all women over the age of 21 be tested for cervical cancer
With more than 500,000 new cases being detected each year, cervical cancer is one of the leading causes of cancer affecting women worldwide.1, 2 A very high burden of cervical cancer mortality is found in developing countries, where nearly 9 out of 10 cases result in cervical cancer-related mortality among women.3, 4 These healthcare disparities can be largely explained by the lack of access to effective cervical cancer screening programs in low-resource settings, such as Sub-Saharan Africa (SSA), that allow for early detection and treatment.5 African women have an extremely high incidence of cervical cancer, with approximately 420,000 new cases, half of which die per year.6 Kenya has the second highest incidence of invasive cervical cancer (ICC) in Africa.6,7 The
Research has demonstrated that there is a low level of awareness among college students regarding risk factors and symptoms of STIs that most threaten them, including HPV(Johnson 2014) According to {Bradley, 2005 #2414} cervical cancer kills a disproportionate number of women in developing countries, despite the fact that evidence-based secondary prevention methods exist . In the study carried out by {Gwag, 2003 #2415} it is found that many women do not attend screening programs because they are not aware of their risk of cervical cancer or of the benefits of screening and early detection and prevention. Several studies conducted in various South Asian countries have reported that between 50-85% of women were knowledgeable or aware of cervical