A patient is displaying an abnormally low increase in stroke volume in response to exercise. Put forward suggestions for the cellular mechanisms that may explain this effect. this is from a past paper but i cant find an example answer
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A patient is displaying an abnormally low increase in stroke volume in response to exercise. Put forward suggestions for the cellular mechanisms that may explain this effect.
this is from a past paper but i cant find an example answer
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- age table, Linergraph a9 MADE IN CHINA O Fined the slape whie ofthe resistance. Discussion 1. Give an example of a biomedical device that follows Ohm's law when functioning 2. Explain how the biomedical device that you mentioned in your answer for the previous question follows Ohm's law. 3. Why do you think that your example is accurate and follows Ohm's law?Vascular endothelial growth factor receptor 2 (VEGFR-2) is an endothelial cell-specific receptor that has inherent tyrosine kinase activity. The binding of the Vascular endothelial growth factor (VEGF) ligand to its receptor plays an important role in angiogenesis, a process by which new capillaries are formed. Enhanced angiogenesis is associated with a number of diseases including cancer. Your goal is to develop a homogeneous in vitro TR-FRET kinase assay for VEGFR-2 (purified protein) in an attempt to identify small molecules that inhibit kinase activity and in turn modulate angiogenesis. Based on this background, please answer the following questions What is the advantage of measuring autophosphorylation of the receptor rather than phosphorylation of the substrate?Vascular endothelial growth factor receptor 2 (VEGFR-2) is an endothelial cell-specific receptor that has inherent tyrosine kinase activity. The binding of the Vascular endothelial growth factor (VEGF) ligand to its receptor plays an important role in angiogenesis, a process by which new capillaries are formed. Enhanced angiogenesis is associated with a number of diseases including cancer. Your goal is to develop a homogeneous in vitro TR-FRET kinase assay for VEGFR-2 (purified protein) in an attempt to identify small molecules that inhibit kinase activity and in turn modulate angiogenesis. Based on this background, please answer the following questions How would you apply a TR-FRET assay to measure the in vitro kinase activity of VEGFR-2? Describe in steps the assay design and potential readout outcome.
- Vascular endothelial growth factor receptor 2 (VEGFR-2) is an endothelial cell-specific receptor that has inherent tyrosine kinase activity. The binding of the Vascular endothelial growth factor (VEGF) ligand to its receptor plays an important role in angiogenesis, a process by which new capillaries are formed. Enhanced angiogenesis is associated with a number of diseases including cancer. Your goal is to develop a homogeneous in vitro TR-FRET kinase assay for VEGFR-2 (purified protein) in an attempt to identify small molecules that inhibit kinase activity and in turn modulate angiogenesis. Based on this background, please answer the following questions While setting up your experiment, you accidentally discovered autophophorylation of receptor. What observation/results led you to believe that there was autophosphorylation of the receptor?Vascular endothelial growth factor receptor 2 (VEGFR-2) is an endothelial cell-specific receptor that has inherent tyrosine kinase activity. The binding of the Vascular endothelial growth factor (VEGF) ligand to its receptor plays an important role in angiogenesis, a process by which new capillaries are formed. Enhanced angiogenesis is associated with a number of diseases including cancer. Your goal is to develop a homogeneous in vitro TR-FRET kinase assay for VEGFR-2 (purified protein) in an attempt to identify small molecules that inhibit kinase activity and in turn modulate angiogenesis. Based on this background, please answer the following questions How would you determine robustness of the assay and validate the assay?Vascular endothelial growth factor receptor 2 (VEGFR-2) is an endothelial cell-specific receptor that has inherent tyrosine kinase activity. The binding of the Vascular endothelial growth factor (VEGF) ligand to its receptor plays an important role in angiogenesis, a process by which new capillaries are formed. Enhanced angiogenesis is associated with a number of diseases including cancer. Your goal is to develop a homogeneous in vitro TR-FRET kinase assay for VEGFR-2 (purified protein) in an attempt to identify small molecules that inhibit kinase activity and in turn modulate angiogenesis. Based on this background, please answer the following questions If you wanted to measure the kinase activity of VEGFR-2, what are some of the conventional methods/assays you would use?
- 3) Cytokinetics is a Bay Area pharmaceutical company that has developed a drug called Tirasemtiv for the treatmentof motor disorders including ALS (amyotrophic lateral sclerosis) and myasthenia gravis. Tirasemtiv acts on skeletal muscle troponin and increases its affinity for calcium. a. Recall the role of calcium in muscle contraction. Describe what would happen if you gave a control patientTirasemtiv. Be sure to include what the effect would be and what you would want to measure to figure outthe difference in activity before and after Tirasemtiv administration. b. In ALS, there is loss of upper and lower motor neurons. In myasthenia gravis, circulating antibodiesblock acetylcholine receptors on the muscle. Describe what motor deficits you would expect to see inpatients with these diseases. c. Describe how you think Tirasemtiv would be useful in the treatment of ALS and myasthenia gravis.What are tyrosine kinase and GPCR? Give example of one pathology that can occur in dysregulation/impaired function for each of these. Hypothetically, how can you rescue the pathologies pharmacologically?A 30-year-old female patient with uncontrolled hypertension is suspected by an investi- gating endocrinologist of having Conn's syndrome. Results of routine biochemistry were (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 2.1 mmol/L 7.2 mmol/L 146 μmol/L 290 IU/L 20 IU/L 49 g/L 8 μmol/L 2.19 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (5-42) (35-50) (<17) (2.12-2.62) (a) Are any of the electrolyte concentrations abnormal, and if so what condition is suggested? (b) What further biochemistry investigations would you undertake? Explain your reasoning.
- Which of the following examples will have longer lasting physiological responses to drug: Group of answer choices A.increase in heart rate following adrenaline infusion B.changes in gene product formation following corticosteroid injectionA 31-year-old woman was diagnosed with serious endogenous depression and was started on treatment with intramuscular imipramine. Imipramine has a FIM of 100%, and a Va of 1134 L. The effective (plasma] for its antidepressant effect is 0.2 mg/L. Calculate the intramuscular dose (in mg) that would be required to successfully achieve the desired effect in this patient. (Use the "square root of x button" to enter math equations in order to show your work.)Ad-dimer will be elevated during: (select all that apply) O ischemic stroke O hemorrhagic stroke reperfusion injury O high intracranial pressure