Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 9.3, Problem 1CS
Summary Introduction
To explain: The reason for the development of cancer because of mutations, which obstruct GTP hydrolysis ability of Ras proteins.
Introduction: Cancer can be defined as an abnormal cellular condition that is characterized by uncontrolled cell division. This condition can result from a large number of cellular, molecular, and
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Q11: You are comparing the process of RNA splicing in an mRNA from normal and mutant cells of the
same tissue. You find that the mutant mRNA is longer than the mRNA from the normal cells.
Examination of the sequences of the gene encoding this mRNA reveals that there are nucleotide
changes at the boundary of one of the exons in the mutant cell gene. Which of the following nucleotides
would be expected to be found at the 3' end of upstream donor exons and the 5' end of downstream
acceptor exons in the normal gene but not in the mutant gene?
A. AG-G
B. AG-AG
C. CA-GA
D. G-AG
E. CG-G
Strength
22. You are analyzing a new human neuronal enhancer.
You cloned the enhancer in front of a minimal promoter,
transfected a neuronal cell line, and quantified GFP
expression. You then performed the deletion analysis
shown on the right. Which letter designates the minimal
region where enhancer activity is located?
min.
Novel enhancer
prom. GFP
of expression
+++
+/-
+++
+/-
+++
a. a
b. b
C. C
+++
+/-
d. d
e. both b and c are needed
Direction: On the worksheet, all the DNA sequences run from 3' to 5'. Supply the corresponding
amino acid base on the DNA sequence provided per item. Determine the type of mutation and
explain its effect on the expression of amino acids.
1.
DNA Sequence: TAC TCC GGC TCT CCC AGT TGA ACT
inim
Mutated Sequence: TAC TCG GCT CTC CCA GTT GAA CT
Original Amino acid:
Mutated Amino Acid:
What mutation have occurred in the sequence? How does it affect the expression of amino
acids?
2.
DNA Sequence: TAC TCC GGC TCT CCC AGT TGA ACT
Mutated Sequence: TAC TCT GGC TCT CCA AGT TGA ACT
ww mm
Original Amino acid:
Mutated Amino Acid:
What mutation has occurred in the sequence? How does it affect the expression of amino
acids?
Chapter 9 Solutions
Biology
Ch. 9.1 - Figure 9.1 Response of a yeast cell to glucose....Ch. 9.1 - Prob. 1CSCh. 9.1 - Which type of signal, paracrine or endocrine, is...Ch. 9.1 - Prob. 3CCCh. 9.2 - Prob. 1CSCh. 9.2 - Prob. 2CSCh. 9.2 - Prob. 1CCCh. 9.3 - Prob. 1CSCh. 9.3 - Prob. 1CCCh. 9.3 - Prob. 2CC
Ch. 9.3 - In the case of signaling pathways involving...Ch. 9.5 - Prob. 1EQCh. 9.5 - Prob. 2EQCh. 9.5 - Prob. 3EQCh. 9.5 - Prob. 1CCCh. 9 - Prob. 1TYCh. 9 - Prob. 2TYCh. 9 - Prob. 3TYCh. 9 - Prob. 4TYCh. 9 - Prob. 5TYCh. 9 - The relay protein Ras is part of the EGF pathway...Ch. 9 - Prob. 7TYCh. 9 - Prob. 8TYCh. 9 - Prob. 9TYCh. 9 - Prob. 10TYCh. 9 - Prob. 1CQCh. 9 - Conceptual Questions What are the three stages of...Ch. 9 - Prob. 3CQCh. 9 - Prob. 1COQCh. 9 - Prob. 2COQ
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