Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Textbook Question
Chapter 4, Problem 16PDQ
While vermilion is X-linked in Drosophila and causes eye color to be bright red, brown is an autosomal recessive mutation that causes the eye to be brown. Flies carrying both mutations lose all pigmentation and are white-eyed. Predict the F1 and F2 results of the following crosses:
(a) vermilion females |
|
brown males |
(b) brown females |
|
vermilion males |
(c) white females |
|
wild males |
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IN DROSOPHILA, AN X-LINKED
RECESSIVE MUTATION, Xm CAUSES
MINIATURE WINGS. LIST
THE F₂ PHENOTYPIC RATIOS IF:
A MINIATURE-WINGED FEMALE IS
CROSSED WITH A NORMAL MALE AND
A MINIATURE-WINGED MALE IS
●
●
CROSSED WITH A NORMAL FEMALE.
WHAT WOULD THE PHENOTYPIC RATIO
FROM (A) BE IF THE MINIATURE-
WINGED GENE WERE AUTOSOMAL?
ASSUME IN ALL CASES THAT THE P1
INDIVIDUALS ARE TRUE-BREEDING.
Vestigial wing is a recessive autosomal mutation in the fruit fly Drosophila melanogaster. Wild-type flies have red eyes, but
another mutation, an X-linked recessive mutation causes white eyes. You cross a parental generation of males with vestigial
wings with females that have white eyes.
1) What phenotypic ratio would you expect in the F1 generation from such a cross? What phenotypes do you observe in
these flies? (e.g. males with red eyes and wild-type wings).
2) What phenotypic ratio would you expect in the F2 generation? What phenotypes do you observe in these flies?
In Drosophila, a cross was made between females—all expressing the three X-linked recessive traits scute bristles (sc), sable body (s), and vermilion eyes (v)—and wild-type males. In the F1, all females were wild type, while all males expressed all three mutant traits. The cross was carried to the F2 generation, and 1000 offspring were counted, with the results shown in the following table. Phenotype Offspring sc s v 314 + + + 280 + s v 150 sc + + 156 sc + v 46 + s + 30 sc s + 10 + + v 14 No determination of sex was made in the data. (a) Using proper nomenclature, determine the genotypes of the P1 and F1 parents. (b) Determine the sequence of the three genes and the map distances between them. (c) Are there more or fewer double crossovers than expected? (d) Calculate the coefficient of coincidence. Does it represent positive or negative interference?
Chapter 4 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 4 - CASE STUDY | But he isn't deaf Researching their...Ch. 4 -
CASE STUDY | But he isn’t deaf
Researching...Ch. 4 - CASE STUDY | But he isn't deaf Researching their...Ch. 4 - HOW DO WE KNOW? In this chapter, we focused on...Ch. 4 - Review the Chapter Concepts list on page 53. These...Ch. 4 - In Shorthorn cattle, coat color may be red, white,...Ch. 4 -
4. With regard to the ABO blood types in humans,...Ch. 4 - In foxes, two alleles of a single gene, P and p,...Ch. 4 - Three gene pairs located on separate autosomes...Ch. 4 - As in the plants of Problem 6, color may be red,...
Ch. 4 -
8. The following genotypes of two independently...Ch. 4 - Given the inheritance pattern of coat color in...Ch. 4 - A husband and wife have normal vision, although...Ch. 4 - In humans, the ABO blood type is under the control...Ch. 4 - In goals, development of the beard is due to a...Ch. 4 -
13. In cats, orange coal color is determined by...Ch. 4 - In Drosophila, an X-linked recessive mutation,...Ch. 4 - Another recessive mutation in Drosophila, ebony...Ch. 4 - While vermilion is X-linked in Drosophila and...Ch. 4 - In pigs, coat color may be sandy, red, or white. A...Ch. 4 - A geneticist from an alien planet that prohibits...Ch. 4 - In another cross, the frog geneticist from Problem...Ch. 4 - In cattle, coats may be solid white, solid black,...Ch. 4 - Consider the following three pedigrees, all...Ch. 4 - Labrador retrievers may be black, brown, or golden...Ch. 4 - Three autosomal recessive mutations in Drosophila,...Ch. 4 -
24. Horses can be cremello (a light cream...Ch. 4 - Pigment in the mouse is produced only when the C...Ch. 4 - Five human matings numbered 1–5 are shown in the...Ch. 4 - Two mothers give birth to sons at the same time at...Ch. 4 - In Dexter and Kerry cattle, animals may be polled...Ch. 4 - What genetic criteria distinguish a case of...Ch. 4 -
30. The specification of the anterior-posterior...Ch. 4 - The maternal-effect mutation bicoid(bcd)is...Ch. 4 -
32. Students taking a genetics exam were...Ch. 4 - In four o'clock plants, many flower colors are...Ch. 4 - Prob. 34PDQ
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- Bicoid is a maternal-effect gene in the fruit fly Drosophila. Recessive mutations in bicoid can result in fly larvae that have no head, and thus are embryonic lethal. Which of the following crosses will result in offspring with the embryonic lethal, no head phenotype? (+ indicates a wild-type allele) O a) bcd /bcd (male) x bcd+/ bcd (female) O b) bcd/ bcd (male) x bcd+/ bcd+ (female) O c) bcd+/ bcd+ (male) x bcd/ bcd (female) O d) bcd+/ bcd (male) x bcd+/bcd (female)arrow_forwardMale Drosophila from a true-breeding wild-type stock were irradiated with X-rays and then mated with females from a true-breeding stock carrying the following recessive mutations on the X chromosome: yellow body (y), crossveinless wings (cv), cut wings (ct), singed bristles (sn), and miniature wings (m). These markers are known to map in the order: Recessive alleles: y, cv, ct, sn, m Dominant alleles: y+, cv+, ct+, sn+, m+ y-cv-ct-sn-m у CV ct sn m X-rays х х X ct sn CV у m y+ CV+ ct+ sn+ m+ х X ? Exceptional female: Most of the female progeny of this cross were phenotypically wild type, but one female exhibited ct and sn mutant characteristics. When this exceptional ct sn female was mated with a male from the true-breeding wild-type stock, twice as many females as males appeared among the progeny. a. What is the nature of the X-ray-induced mutation present in the exceptional female? b. Draw the X chromosomes present in the exceptional ct sn female as they would appear during pairing…arrow_forwardThe phenotype of crooked wings (cw) in Drosophila melanogaster is caused by a recessive mutant gene that independently assorts with a recessive mutant gene for hairy (h) body. Assume that a cross is made between a fly with normal wings and a hairy body and a fly with crooked wings and normal body hair. All F1 flies from this cross were wild-type, and these flies were crossed among each other to produce 288 F2 offspring. Which phenotypes would you expect among the offspring in the F2 generation, and how many of each phenotype would you expect?arrow_forward
- The phenotype of vestigial (short) wings (vg) in Drosophila melanogaster is caused by a recessive mutant gene that independently assorts with a recessive gene for hairy (h) body. Assume that a cross is made between a fly that is homozygous for normal wings and has a hairy body and a fly with vestigial wings that is homozygous for normal body. The wild-type F1 flies were crossed among each other to produce 1024 F2 offspring. Which phenotypes would you expect among the F2 offspring, and how many of each phenotype would you expect? Group of answer choices 192 wild type, 256 vestigial, 64 hairy, and 192 vestigial and hairy All vestigial and hairy. 576 wild type, 192 vestigial, 192 hairy, and 64 vestigial and hairy All wild type 256 wild type; 256 vestigial, 256 hairy, and 256 vestigial and hairyarrow_forwardA mutant sex-linked trait called “notched” (N) is deadly in Drosophila when homozygous in females. Males who have a single N allele will also die. The heterozygous condition (Nn) causes small notches on the wing. The normal condition in both male and females is represented by the allele n. a) Indicate the phenotypes of the F1 generation from the following cross: XNXn x XnY b) Explain why dead females are never found in the F1 generation no matter which parents are crossed. c) Explain why the mating of female XNXn and a male XNy is unlikely.arrow_forwardMiniature wings (Xm) in Drosophila result from an X-linked allele that is recessive to the allele for long wings (X*). Give the genotypes of the parents in the following cross: Male parent Female parent Male offspring Female offspring Long Miniature 750 miniature 761 long O male: X* / X* and female X™ /x+ O male: X*/Xt and female Xm /xm O male: X*/ Y and female Xm /xm O male: Xm/ Y and female Xm /xmarrow_forward
- In Drosophila,, the curled mutation (cu, chromosome 3, position 50.0) results in wings that curl up, while ebony (e, chromosome 3, position 70.7) results in a dark body. True breeding, wild type females are mated with true breeding males with curled wings and ebony bodies. Considering Drosophila notation, which of the following correctly diagrams the P1 cross? X X ++ e + + + O+ X + X + ■ + X + + + 3+ X X X X + + Y Y cu cu cu + cu cu J e e e e e (D e + cu cu (Darrow_forwardConsider the following three autosomal recessive mutations in Drosophila:vestigial wings (v); wild type is long (v+)black body color (b); wildtype is gray (b+)plum eyes (p); wildtype is red (p+)A vestigal, gray, red female (homozygous for all three genes) is crossed with a long wing, black, plum male (homozygous for all three genes). The F1 female progeny are mated with triple homozygous recessive males. Here is the phenotypic data for the F2 progeny:vestigal; gray; red 580long wings; black; plum 592vestigal; black; red 45long; gray; plum 40vestigal; black; plum 89long; gray; red 94vestigal; gray; plum 3long; black; red 5A total of 1448 progeny were counted.Which one of the following values is the approximate distance between the plum eye color and black body color loci?arrow_forwardIn Drosophila,, the curled mutation (cu, chromosome 3, position 50.0) results in wings that curl up, while ebony (e, chromosome 3, position 70.7) results in a dark body. True breeding, wild type females are mated with true breeding males with curled wings and ebony bodies. Considering Drosophila notation, which of the following correctly diagrams the F1 cross? X X 3+ cu e + X X e + + + + + cu e + O + ■ 3+ X X X X Y Y + + ■ cu cu cu ' + ■ cu ■ ' + e + e e e e e + cu +arrow_forward
- In Drosophila, the X-linked recessive mutation vermilion (v) causes bright red eyes, in contrast to the brick-red eyes of wild type. A separate autosomal recessive mutation, suppressor of vermilion (su-v), causes flies homozygous or hemizygous for v to have wildtype eyes. In the absence of vermilion alleles, su-v has no effect on eye color. Determine the F1 and F2 phenotypic ratios from a cross between a female with wild-type alleles at the vermilion locus, but who is homozygous for su-v, with a vermilion male who has wildtype alleles at the su-v locusarrow_forwardBar (B) is a dominant sex-linked mutant of D. melanogaster. Held-out wings and ebony body are recessive, autosomal mutants on chromosome III, mapping 12 map units apart. A Bar-eyed, ebony-bodied male was crossed to a held-out female, and the resulting F1 progeny WERE INBRED to produce the F2. At what frequency do you expect wild-type flies from this cross? (Reminder: Crossing over does not occur in the male). Based on the information in Problem 3, how often would you get a bar ebony but not held-out progeny?arrow_forwardThree recessive mutations in Drosophila melanogaster, roughoid (ru, small rough eyes), javelin (jv, cylindrical bristles), and sepia eyes (se, dark brown eyes) are linked. A three-point cross was carried out and the following progeny obtained: jv+ ru+ se+ 37 jv+ ru+ se 2 jv+ ru se 14 jv+ ru se+ 146 jv ru se+ 2 jv ru se 35 jv ru+ se 154 jv ru+ se+ 10 a. Determine the order of the genes on the chromosome. b. Determine which progeny contain single crossovers and which contain double crossovers and indicate where among the genes the crossovers occurred. c. Calculate the map distances among the genes. d. Calculate the coefficient of coincidence and interference among the genesarrow_forward
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