Elastase

tissue from patients with emphysema (GOLD IV) was obtained from lung volume reduction surgery through Temple Biobank at Temple University, Philadelphia, PA (N = … per group). ATII cells were isolated as we previously described (REF). Briefly, after elastase (Roche Diagnostics,

Introduction Cystic fibrosis is an inherited disease that ultimately leads to death. It affects every racial group worldwide, but its prevalence varies from country to country. In those with cystic fibrosis, the lungs and digestive system are primarily affected by the disease. With the new developments in treatment and management, the 50 percent survival rate from the 1970’s has greatly improved, allowing patients to continue to live their lives longer than ever expected in the past. The new

Introduction The topic is Chronic Obstructive Pulmonary Disease (COPD). It is an umbrella term used for respiratory disorders such as chronic asthma, chronic bronchitis and emphysema. It is a serious condition that restricts airflow to the lungs and is not fully reversible. It is a major cause of morbidity and mortality in Australia. More than 1 in 20 Australians over 55 have COPD and is also the fifth leading cause of death. There is also a rate of 1,008 per 100,000 of the population aged 55 and

Introduction: Our environment contains countless contaminants such as bacteria, toxins, virus and parasites, many of which pose a direct threat to the wellbeing of the host. As such, multicellular organisms have evolved specific mechanisms to protect from the extensive threats that would otherwise cause disease and possibly death. The most basic and primordial defense mechanism employed by such hosts is that of antimicrobial peptides (AMP) that possess the ability to preferentially bind to

Pseudomonas aeruginosa Pseudomonas aeruginosa is a versatile gram negative bacterium that grows in soil, marshes, and coastal marine habitats, as well as on plant and animal tissues. People with cystic fibrosis, burn victims, individuals with cancer, and persons infected with HIV are particularly at risk of disease resulting from Pseudomonas aeruginosa. Unlike many environmental bacteria, Pseudomonas aeruginosa has a remarkable capacity to cause disease in susceptible hosts. It

While inflammation is often viewed in a negative connotation, inflammation is actually an essential component of the healing process. Inflammation is commonly associated with pain, swelling, and redness; however, these effects are the body’s natural response to injury as blood and white blood cells move into the tissue and stimulate the repair process.2, 29 Therefore it is important to understand that even though certain molecular signals are traditionally identified as pro-inflammatory molecules

Acute Inflammation The survival of all organisms requires that they eliminate foreign invaders, such as infectious pathogens, and damaged tissues. These functions are mediated by a complex host response called inflammation. Definition of inflammation Inflammation is fundamentally a protective response, the ultimate goal of which is to rid the organism of both the initial cause of cell injury (e.g., microbes, toxins) and the consequences of such injury (e.g., necrotic cells and tissues)

1.1 The HIV Pandemic: The ongoing Human Immunodeficiency Virus (HIV) pandemic has and continues to devastate many individuals across the globe, leaving children orphaned, families fractured, and local economies disrupted. The first known and confirmed case of HIV infection dates back to 1959 [1], however AIDS-related pathologies were not recognized as interrelated outcomes from the same disease until 1981 when clusters of young, homosexual men in New York City and Los Angeles began presenting with

Name: _Leroy Johnson __________________________________ Date: ______________Comprehensive Study Guide. Test will only be Multiple choice 1. The feature that most clearly separates eukaryotes from prokaryotes is the presence of _______ in eukaryotic cells. A) ribosomes B) oxidative phosphorylation C) DNA molecules -D) a nucleus 2. Cytoplasmic organelles are - A) absent in prokaryotic cells; present in eukaryotic cells. B) present in both prokaryotic and eukaryotic cells