Principles of Human Physiology (6th Edition)
6th Edition
ISBN: 9780134169804
Author: Cindy L. Stanfield
Publisher: PEARSON
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Chapter 7, Problem 25E
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With regard to Na+ and K+ equilibrium potentials and the resting and active membrane potentials, write down (a-
D the directions of the forces indicated, acting on the ion in the table below under the respective condition(s). NB
the examples given.
lon
Condition
Electrical/Chemical force
Direction of force
Chemical
e.g....inward..
******
Na
ENa+ = + 60 mV
Electrical
a.
Chemical
e.g. ...outward..
EK+ =- 90 mV
Electrical
b.
Chemical
C.
Na"
Emp = 0 mV
Electrical
d.
Chemical
K+
Emp
=-20 mV
Electrical
Hyperkalemia is a condition by which ECF potassium levels become too high (usually due to kidney failure). Consider the following questions about the consequence of hyperkalemia on membrane potential.
How would hyperkalemia affect EK?
Considering your answer to the previous question, how would hyperkalemia affect membrane potential?
The membrane potential for an excitable cell membrane is -70 mV, for sodium ions the Nernst equilibrium potential is +50 mV, the conductivity of the single sodium channel is 10 pS. What is the electrochemical potential difference that is the driving force for sodium ions to migrate? How much current flows through an open sodium channel under these conditions?
Chapter 7 Solutions
Principles of Human Physiology (6th Edition)
Ch. 7.2 -
Name the different parts, divisions, and...Ch. 7.2 - Prob. 7.1.2QCCh. 7.2 - Prob. 7.1.3QCCh. 7.3 - Prob. 7.2.1QCCh. 7.3 - Prob. 7.2.2QCCh. 7.3 - If channels that permitted both sodium ions and...Ch. 7.4 - Prob. 1CTQCh. 7.4 - Prob. 2CTQCh. 7.4 - Prob. 3CTQCh. 7.4 - Prob. 7.3.1QC
Ch. 7.4 - Prob. 7.3.2QCCh. 7.4 - Prob. 7.3.3QCCh. 7.4 - During the depolarization of an action potential,...Ch. 7.4 - Compare the gating mechanisms of the voltage-gated...Ch. 7.4 - During which phase of an action potential are the...Ch. 7.4 - Prob. 7.5.1QCCh. 7.4 - Prob. 7.5.2QCCh. 7.4 - Prob. 7.5.3QCCh. 7.4 - Prob. 1aCTQCh. 7.4 - Prob. 2aCTQCh. 7.4 - Prob. 3aCTQCh. 7.5 - Prob. 7.6.1QCCh. 7.5 - Prob. 7.6.2QCCh. 7.5 - Prob. 7.6.3QCCh. 7 - Prob. 1ECh. 7 - Neurotransmitters are released most commonly from...Ch. 7 - If a cation is equally distributed across the cell...Ch. 7 -
The depolarization phase of an action potential...Ch. 7 - During the relative refractory period, a second...Ch. 7 - Prob. 6ECh. 7 - If the membrane potential of a neuron becomes more...Ch. 7 - Prob. 8ECh. 7 - Prob. 9ECh. 7 - Prob. 10ECh. 7 - Prob. 11ECh. 7 - Prob. 12ECh. 7 - Prob. 13ECh. 7 - Prob. 14ECh. 7 - Which Of the following statements about graded...Ch. 7 -
What are the subdivisions of the peripheral...Ch. 7 -
Information from the periphery is brought to the...Ch. 7 -
Which cell type is more abundant in the nervous...Ch. 7 - Voltage-gated calcium channels are located in...Ch. 7 - Prob. 20ECh. 7 - Prob. 21ECh. 7 - Prob. 22ECh. 7 - Prob. 23ECh. 7 - Prob. 24ECh. 7 - The electrochemical force for potassium ions when...Ch. 7 -
Both sodium and potassium channels have...Ch. 7 - Prob. 27ECh. 7 -
In myelinated axons, action potentials are...Ch. 7 -
The Na+ Ka+ pump causes the repolarization phase...Ch. 7 -
When a neuron is at the peak of an action...Ch. 7 - Prob. 31ECh. 7 - Prob. 32ECh. 7 - Prob. 33ECh. 7 - Prob. 34ECh. 7 - Prob. 35ECh. 7 -
Muscle cells, like neurons, are excitable cells...Ch. 7 - Prob. 37ECh. 7 - Prob. 38ECh. 7 -
Predict what would happen to the resting...
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- Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)arrow_forwardA cell has an actual membrane potential (Em) at rest of -75mV. The equilibrium potential for Na+ is +120mV and the equilibrium potential for K+ is -95mV. Calculate the net driving force for Na+ in mV.arrow_forwardAt the peak of the action potential, Vm is approximately -65 mV. Assuming normal intracellular and extracellular K+ concentrations (refer to the table), (1) calculate the driving force (in mV) that acts on K+ ions and (2) use the information obtained in part 1 to determine the direction in which K+ ions will flow (i.e., into the cell or out of cell)arrow_forward
- Describe the contribution of each of the following to the establishment and maintenance of membrane potential: Part A Na+K+ Pump Passive movement of K+ across the membrane Passive movement of Na+ across the membrane Part B Resting membrane potential is approximately -70mV. Explain what resting membrane potential is and what -70mV refers to.arrow_forwardCalculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50 M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane equally permeable to both ions.arrow_forwardGraded potentials and action potentials are both changes in membrane potential created by ion movement between the extracellular and intracellular fluids.arrow_forward
- Describe the contribution of each of the following to the establishment and maintenance of membrane potential: Part A Na+K+ Pump Passive movement of K+ across the membrane Passive movement of Na+ across the membranearrow_forwardCalculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). (a)Membrane permeable only to Na+.arrow_forwardThe membrane potential caused by differences in ions across the plasma membrane of an electrically excitable cell (when not stimulated) is called: action potential resting membrane potential graded potential local potentialarrow_forward
- Given that the extracellular concentration of Cl- is approximately 120 mM, what is the intracellular concentration if the Nernst potential for Cl- is 39 mV. (T=298 K, R=1.987 cal/K·mol, F=23,062 cal/mol·V)arrow_forwardMembrane potential in cells is constantly fluctuating. These fluctuations are called graded potentials and we will learn more about them in future lectures. Look at the fluctuating graded potential in the graph as an example. If Cl- generally has a relatively low membrane permeability, how would increasing Cl- permeability affect this graph?arrow_forwardWhich of the following intracellular potentials would have the greatest electrical attraction for Na+ to enter the cell? -70mV Ⓒ) -100mV -50mV OmV +20mVarrow_forward
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