Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 7, Problem 18P
Interpretation Introduction
Interpretation:
The effect of mutations that placed the
Concept introduction:
The protein which contains oxygen and is present in the red blood cells in the body is known as hemoglobin. It contains iron as well.
The process of alteration of DNA sequence or base pair of DNA in a normal gene that forms a mutant gene is known as mutation.
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Hemoglobin variant Yakima contains His rather than Asp at the 99th
description of hemoglobin Yakima.
(Hint! Asp(99)B > His disrupts a H-bond that stabilizes the T state).
position of each B chain (or the 1st position of G helix in B chain). Choose the best
The p50 value of hemoglobin Yakima is lower than p50 of normal hemoglobin.
O B. The p50 value of hemoglobin Yakima is higher than p50 of normal hemoglobin.
The p50 value is not changed in hemoglobin Yakima.
C.
Hemoglobin Yakima will not bind O2
O D.
O E. All of the above
2,3-Bisphosphoglycerate lies in a central cavity within the hemoglobin tetramer, stabilizing the T state. What would be the effect of mutations that placed the BPG-binding site on the surface of hemoglobin?
Please help me with this question. PLEase give me the right answer and for number 2 WRITE AT LEAST A PARAGRAPGH and dont copy from internet.
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