Campbell Biology in Focus (2nd Edition)
2nd Edition
ISBN: 9780321962751
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece
Publisher: PEARSON
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Textbook Question
Chapter 5.6, Problem 1CC
During an epinephrine-initiated signal in liver cells, in which of the three stages of cell signaling does glycogen phosphorylase act?
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In liver cells, glycogen phosphorylase acts in which of the three stages of the signaling pathway associated with an epinephrine-initiated signal?
In liver and muscle, epinephrine stimulation of the cAMP pathway activates glycogen breakdown and inhibits glycogen synthesis, whereas in adipose tissue, epinephrine activates hydrolysis of triglycerides, and in other cells, it causes a diversity of other responses. What step in the cAMP signaling pathways in these cells specifies the cell response?
What are the three main parts of a signaling pathway? Give a detailed specific example, such as how epinephrine signals for rapid digestion of glycogen in liver cells.
Chapter 5 Solutions
Campbell Biology in Focus (2nd Edition)
Ch. 5.1 - Plasma membrane proteins have carbohydrates...Ch. 5.1 - WHAT IF? How would the membrane lipid composition...Ch. 5.2 - What property allows O2 and CO2, to cross a lipid...Ch. 5.2 - Why is a transport protein needed to move many...Ch. 5.2 - MAKE CONNECTIONS Aquaporins exclude passage of...Ch. 5.3 - How do you think a cell performing cellular...Ch. 5.3 - WHAT IF? If a Paramecium caudatum cell swims from...Ch. 5.4 - Sodium-potassium pumps help nerve cells establish...Ch. 5.4 - Prob. 2CCCh. 5.4 - MAKE CONNECTIONS Review the characteristics of the...
Ch. 5.5 - As a cell grows, its plasma membrane expands. Does...Ch. 5.5 - Prob. 2CCCh. 5.5 - MAKE CONNECTIONS In Concept 4.7, you learned that...Ch. 5.6 - During an epinephrine-initiated signal in liver...Ch. 5.6 - When a signal transduction pathway involves a...Ch. 5.6 - WHAT IF? How can a target cells response to a...Ch. 5 - In what way do the membranes of a eukaryotic cell...Ch. 5 - Which of the following factors would tend to...Ch. 5 - Phosphorylation cascades involving a series of...Ch. 5 - Lipid-soluble signaling molecules, such as...Ch. 5 - Which of the following processes includes all the...Ch. 5 - Based on Figure 5.17.which of these experimental...Ch. 5 - Prob. 7TYUCh. 5 - SCIENCE, TECHNOLOGY, AND SOCIETY Extensive...Ch. 5 - FOCUS ON EVOLUTION Paramecium and other...Ch. 5 - FOCUS ON INTERACTIONS A human pancreatic cell...Ch. 5 - SYNTHESIZE YOUR KNOWLEDGE In the supermarket,...
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- (a) Predict the effect of a mutation that enhances the activity of the kinase associated with the PDH complex. (b) Predict the effect of a mutation that reduces the activity of the phosphatase associated with the PDH complex.arrow_forwardSignaling by soluble extracellular molecules can be classified as endocrine, paracrine, or autocrine. Describe how these three types of cellular signaling differ. Growth hormone is secreted from the pituitary, which is located at the base of the brain and acts through growth hormone receptors located on the liver. Is this an example of endocrine, paracrine, or autocrine signaling? Why?arrow_forwardAnother general principle of physiology states that physiological processes require the transfer and balance of matter and energy. How is energy balance-related to intracellular signaling?arrow_forward
- In early studies of adrenergic signaling, it was thought that the epinephrine receptor and adenylate cyclase were one and the same protein. What kind of evidence would prove otherwise?arrow_forwardIn muscle cells, when adrenaline binds to beta-adrenergic receptor, it trigger signaling cascade leading to active glycogen phosphorylate breaks up glycogen into glucose subunits (Glycogen -> G1P). Base on following figure, describe this signaling cascade:arrow_forwardDescribe two features of insulin signaling that affect glucose utilization. Aβ-adrenergic response can be modulated through the actions of a receptorkinase and arrestin because phosphorylation by the kinase desensitizes thereceptor. How might signaling by a tyrosine receptor kinase, such as theinsulin receptor, be modulated?arrow_forward
- Nerve-growth factor (NGF) binds to a protein tyrosine kinase receptor. The amount of diacylglycerol in the plasma membrane increases in cells expressing this receptor when treated with NGF. Propose a simple signaling pathway and identify the isoform of any participating enzymes. Would you expect the concentrations of any other common second messengers to increase on NGF treatment?arrow_forwardA mutated form of the α subunit of the heterotrimeric G protein has been identified; this form readily exchanges nucleotides even in the absence of an activated receptor. What would be the effect on a signaling pathway containing the mutated α subunit?arrow_forwardwhen kidney cells secrete low levels of oxygen in the blood they secrete erythropoietin. in this particular signaling pathway (response to low oxygen) the secretion of erythropoietin represents which step of the signal transdution process?arrow_forward
- What kind of protein is the reactor in insulin signaling pathway: a ligand-gated channel, a G protein-linked receptor, or an enzyme- linked receptor? The receptor activates a specific kind of protein, Based on what that protein does, what is it called?arrow_forwardSuppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein binding to a receptor. How might this mutation affect signaling involving a GPCR? Which subunit of the G protein is most likely affected by the mutation?arrow_forwardIn some forms of diabetes, a mutation in the b subunit of the insulin receptor abolishes the enzymatic activity of that subunit. How does the mutation affect the cell’s response to insulin? Can additional insulin (e.g., from injections) overcome the defect?arrow_forward
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