Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
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Chapter 5, Problem 45P
To determine
Explain the effect of each treatment regimen on the changes in the heart rate.
Check whether the distribution of changes is normal or not.
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A pharmaceutical company tested the impact of four cholesterol-reducing medications
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one of the four medications. The subjects were instructed to take one tablet per day
for a period of three months after which their LDL levels were again measured. Below
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| Medication A | Medication B | Medication C Medication D
31
30
31
30
32
31.5
32
35
29
30.5
29.75
27
33
30.5
31.75
31
29
31.5
33
29
(a) Write an appropriate statistical model (to represent the responses using an appro-
priate equation) to describe the above data. Describe all symbols/notations used in
the model.
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A deficiency of the trace element selenium in the diet can negatively impact growth, immunity, muscle and neuromuscular function, and fertility. The introduction of selenium supplements to dairy cows is justified when pastures have low selenium levels. Authors of a research paper supplied the following data on milk selenium concentration (mg/L) for a sample of cows given a selenium supplement (the treatment group) and a control sample given no supplement, both initially and after a 9-day period.
Initial Measurement
Treatment
Control
11.4
9.1
9.6
8.7
10.1
9.7
8.5
10.8
10.2
10.9
10.6
10.6
11.9
10.1
9.9
12.3
10.7
8.8
10.2
10.4
10.3
10.9
11.4
10.4
9.3
11.6
10.6
10.9
10.9
8.3
After 9 Days
Treatment
Control
138.3
9.2
104
8.9
96.4
8.9
89
10.1
88
9.6
103.8
8.6
147.3
10.4
97.1
12.4
172.6
9.2
146.3
9.5
99
8.4
122.3
8.8
103
12.5
117.8
9.1
121.5
93
(a)
Use the given data for the treatment group to determine if…
A deficiency of the trace element selenium in the diet can negatively impact growth, immunity, muscle and neuromuscular function, and fertility. The introduction of selenium supplements to dairy cows is justified when pastures have low selenium levels. Authors of a research paper supplied the following data on milk selenium concentration (mg/L) for a sample of cows given a selenium supplement (the treatment group) and a control sample given no supplement, both initially and after a 9-day period.
Initial Measurement
Treatment
Control
11.2
9.1
9.6
8.7
10.1
9.7
8.5
10.8
10.3
10.9
10.6
10.6
11.7
10.1
9.7
12.3
10.8
8.8
10.3
10.4
10.4
10.9
11.2
10.4
9.4
11.6
10.6
10.9
10.7
8.4
After 9 Days
Treatment
Control
138.3
9.3
104
8.7
96.4
8.7
89
10.1
88
9.6
103.8
8.6
147.3
10.2
97.1
12.2
172.6
9.3
146.3
9.5
99
8.2
122.3
8.9
103
12.5
117.8
9.1
121.5
93
(a)
Use the given data for the treatment group to determine if there…
Chapter 5 Solutions
Fundamentals of Biostatistics
Ch. 5.4 - What is the difference between a...Ch. 5.4 - Suppose a continuous random variable can only take...Ch. 5.4 - What is a standard normal distribution?Ch. 5.4 - (a) What is the area to the left of 0.2 under a...Ch. 5.4 - (a) What is z.30? What does it mean? (b) What is...Ch. 5.5 - What is the difference between a standard normal...Ch. 5.5 - What does the principle of standardization mean?Ch. 5.5 - Suppose the distribution of serum-cholesterol...Ch. 5.8 - Why do we use the normal approximation to the...Ch. 5.8 - Prob. C.2RE
Ch. 5.8 - The prevalence of glaucoma among the elderly in...Ch. 5.8 - The number of deaths from heart failure in a...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Suppose that total carbohydrate intake in 12- to...Ch. 5 - Suppose that total carbohydrate intake in 12- to...Ch. 5 - Suppose boys in this age range who live below the...Ch. 5 - Suppose boys in this age range who live below the...Ch. 5 - A study was conducted assessing the effect of...Ch. 5 - A study was conducted assessing the effect of...Ch. 5 - The duration of cigarette smoking has been linked...Ch. 5 - The duration of cigarette smoking has been linked...Ch. 5 - Serum cholesterol is an important risk factor for...Ch. 5 - Serum cholesterol is an important risk factor for...Ch. 5 - Serum cholesterol is an important risk factor for...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - In pharmacologic research a variety of clinical...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - Is the measure in Problem 5.38 a measure of...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - Refer to the pulmonary-function data in the Data...Ch. 5 - Prob. 43PCh. 5 - Refer to the pulmonary-function data in the Data...Ch. 5 - Prob. 45PCh. 5 - A clinical trial was conducted to test the...Ch. 5 - Well-known racial differences in blood pressure...Ch. 5 - Well-known racial differences in blood pressure...Ch. 5 - Prob. 49PCh. 5 - Suppose we observe 84 alcoholics with cirrhosis of...Ch. 5 - What is the probability of observing at least 29...Ch. 5 - Suppose we observe 84 alcoholics with cirrhosis of...Ch. 5 - FIGURE 5.22 Plasma-aldosterone concentrations in...Ch. 5 - FIGURE 5.22 Plasma-aldosterone concentrations in...Ch. 5 - Pregnant women with gestational diabetes mellitus...Ch. 5 - Officials in the State Health Department are...Ch. 5 - Prob. 57PCh. 5 - A study was conducted relating particulate air...Ch. 5 - Prob. 59PCh. 5 - Refer to Data Set VALID.DAT (at...Ch. 5 - Refer to Data Set VALID.DAT (at...Ch. 5 - Prob. 62PCh. 5 - A study concerned the risk of cancer among...Ch. 5 - Prob. 64PCh. 5 - A doctor diagnoses a patient as hypertensive and...Ch. 5 - A doctor diagnoses a patient as hypertensive and...Ch. 5 - Suppose the physician is not sure whether the...Ch. 5 - A study compared different treatments for...Ch. 5 - A study compared different treatments for...Ch. 5 - A study compared different treatments for...Ch. 5 - Obesity is an important determinant of...Ch. 5 - Prob. 72PCh. 5 - Prob. 73PCh. 5 - Prob. 74PCh. 5 - Prob. 75PCh. 5 - Prob. 76PCh. 5 - Answer the question in Problem 5.75 for a binomial...Ch. 5 - Prob. 78PCh. 5 - Prob. 79PCh. 5 - Prob. 81PCh. 5 - Prob. 82PCh. 5 - Prob. 83PCh. 5 - Prob. 85PCh. 5 - Retinitis pigmentosa (RP) is a genetic ocular...Ch. 5 - Prob. 87PCh. 5 - Prob. 88PCh. 5 - Prob. 89PCh. 5 - Physicians recommend that children with type-I...Ch. 5 - Physicians recommend that children with type-I...Ch. 5 - Prob. 92PCh. 5 - Prob. 93PCh. 5 - Prob. 94PCh. 5 - Prob. 95PCh. 5 - A previous study found that people consuming large...Ch. 5 - A previous study found that people consuming large...Ch. 5 - Prob. 98PCh. 5 - A study was recently published in Western...Ch. 5 - Prob. 100PCh. 5 - Prob. 101PCh. 5 - Prob. 102PCh. 5 - Prob. 103PCh. 5 - Prob. 104PCh. 5 - Prob. 105PCh. 5 - What is the 40th percentile of a normal...Ch. 5 - What is the sum of the 40th and 60th percentiles...Ch. 5 - What is z.90?Ch. 5 - A study was performed of different predictors of...Ch. 5 - A study was performed of different predictors of...Ch. 5 - Prob. 111PCh. 5 - Prob. 112PCh. 5 - Cancer The Shanghai Womens Health Study (SWHS) was...Ch. 5 - Prob. 114PCh. 5 - Prob. 115PCh. 5 - Prob. 116PCh. 5 - Prob. 117PCh. 5 - Prob. 118PCh. 5 - Prob. 119PCh. 5 - Prob. 120PCh. 5 - Prob. 121PCh. 5 - Prob. 122PCh. 5 - Prob. 123PCh. 5 - Prob. 124PCh. 5 - Hypertension Blood pressure readings are known to...Ch. 5 - Prob. 126PCh. 5 - Prob. 127PCh. 5 - Prob. 128PCh. 5 - Prob. 129PCh. 5 - Prob. 130P
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- A deficiency of the trace element selenium in the diet can negatively impact growth, immunity, muscle and neuromuscular function, and fertility. The introduction of selenium supplements to dairy cows is justified when pastures have low selenium levels. Authors of a research paper supplied the following data on milk selenium concentration (mg/L) for a sample of cows given a selenium supplement (the treatment group) and a control sample given no supplement, both initially and after a 9-day period. Initial Measurement Treatment Control 11.3 9.1 9.7 8.7 10.1 9.7 8.5 10.8 10.4 10.9 10.7 10.6 11.8 10.1 9.8 12.3 10.6 8.8 10.4 10.4 10.2 10.9 11.3 10.4 9.2 11.6 10.7 10.9 10.8 8.2 After 9 Days Treatment Control 138.3 9.4 104 8.8 96.4 8.8 89 10.1 88 9.7 103.8 8.7 147.3 10.3 97.1 12.3 172.6 9.4 146.3 9.5 99 8.3 122.3 8.9 103 12.5 117.8 9.1 121.5 93 (a) Use the given data for the treatment group to determine if…arrow_forwardA recent study on the effects of Tamiflu looked into whether the antiviral medication can reduce the duration of the flu or not. To test this, researchers selected sample of 42 individuals recently diagnosed with the flu. Twenty-one of these individuals were given a placebo, and their average flu durations was 12.6 days (SD = 1.88). The remaining 21 subjects were given Tamiflu, and their average flu duration was 11.4 days (SD = 1.58). Did Tamiflu make reduce the duration of the flu? What is the effect size for this difference? state the null and alternavive hypthesis, aplha level of 0.05 please text the null hypthesis and draw the rejction regionarrow_forwardVermont maple sugar producers sponsored a testing program to determine the benefit of a potential new fertilizer regimen. A random sample of 27 maple trees in Vermont were chosen and treated with one of three levels of fertilizer suggested by the chemical producer. In this experimental setup, nine trees (three in each of three climatic zones) were treated with each fertilizer level and the amount of sap produced (in mL) by the trees in the subsequent season was measured. The results are presented in the following table. Southern Zone Central Zone Northern Zone 76.2 80.4 74.2 79.4 87.9 86.9 84.5 85.2 80.1 Low fertilizer Medium 87.0 95.1 93.0 98.2 94.7 96.2 88.4 90.4 922 fertilizer High 84.2 87.5 83.1 90.3 89.9 93.2 81.4 84.7 82.2 fertilizer Estimate the main effects of fertilizer levels and climatic zone, and their interactions. b. Construct an ANOVA table. You may give ranges for the P-values. Test the hypothesis that there is no interaction between fertilizer levels and climatic zone.…arrow_forward
- A study was designed "to determine if application of duct tape is as effective as cryotherapy (liquid nitrogen applied to the wart for 10 seconds every 2 to 3 weeks) in the treatment of common warts." The researchers randomly divided 51 patients into two groups. The 26 patients in group 1 had their warts treated by applying duct tape to the wart for 6.5 days and then removing the tape for 12 hours, at which point the cycle was repeated for a maximum of 2 months. The 25 patients in group 2 had their warts treated by cryotherapy for a maximum of six treatments. Once the treatments were complete, it was determined that 85% of the patients in group 1 and 60% of the patients in group 2 had complete resolution of their warts. The researchers concluded that duct tape is significantly more effective in treating warts than cryotherapy. What is the research objective? What is the population being studied? What is the sample? What are the descriptive statistics? What are the conclusions of the…arrow_forwardA study was conducted to examine the effect of diet cola consumption on calcium levels in women. A sample of 16 healthy women aged 18 to 40 were randomly assigned to drink 24 ounces of either diet cola or water. Their urine was collected for three hours after ingestion of the beverage and calcium excretion (in mg) was measured. The data are stored in ColaCalcium.arrow_forwardResearchers interested in lead exposure due to car exhaust sampled the blood of 52 police officers subjected to constant inhalation of automobile exhaust fumes while working traffic enforcement in a primarily urban environment. The blood samples of these officers had an average lead concentration of 124.32 µg/l and a SD of 37.74 µg/l; a previous study of individuals from a nearby suburb, with no history of exposure, found an average blood level concentration of 35 µg/l. Based on your preceding result, without performing a calculation, would a 99% confidence interval for the average blood concentration level of police officers contain 35 µg/l? Based on your preceding result, without performing a calculation, would a 99% confidence interval for this difference contain 0? Explain why or why not.arrow_forward
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