Loose Leaf For Integrated Principles Of Zoology
18th Edition
ISBN: 9781260411140
Author: Cleveland P Hickman Jr. Emeritus, Susan L. Keen, David J Eisenhour Professor PhD, Allan Larson, Helen I'Anson Associate Professor of Biology
Publisher: McGraw-Hill Education
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Chapter 5, Problem 24RQ
Summary Introduction
To explain: The Ras protein and p53.
Introduction: Spontaneous or induced damage to cells causes mutations. The mutations in genes that regulate cell growth either inhibiting or promoting, result in abnormal uncontrolled growth. The accumulation of these mutations leads to cancer.
Summary Introduction
To explain: The way mutation in Ras and p53 gene contribute to cancer.
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What are Ras protein and p53? How can mutations in the genes for these proteins contribute to cancer?
what are the rolls that the p53 gene and RAS protein take on when trying to stop a cancer cell from further replicating. Also, what would happen if a mutation were to occur in both genes?
What is Cancer Epigenetics ?
Chapter 5 Solutions
Loose Leaf For Integrated Principles Of Zoology
Ch. 5 - What is the relationship between homologous...Ch. 5 - Describe or diagram the sequence of events in...Ch. 5 - What are the designations of the sex chromosomes...Ch. 5 - Prob. 4RQCh. 5 - Diagram by Punnett square a cross between...Ch. 5 - Prob. 6RQCh. 5 - Assuming brown eyes (B) are dominant over blue...Ch. 5 - Prob. 8RQCh. 5 - Prob. 9RQCh. 5 - Prob. 10RQ
Ch. 5 - Assume that right-handedness (R) is genetically...Ch. 5 - Prob. 12RQCh. 5 - Prob. 13RQCh. 5 - Distinguish the following: euploidy, aneuploidy,...Ch. 5 - Prob. 15RQCh. 5 - Prob. 16RQCh. 5 - Prob. 17RQCh. 5 - Prob. 18RQCh. 5 - Prob. 19RQCh. 5 - Prob. 20RQCh. 5 - Prob. 21RQCh. 5 - Why do many mutations have no detectable effects...Ch. 5 - Distinguish between proto-oncogene and oncogene....Ch. 5 - Prob. 24RQCh. 5 - Outline the essential steps in the polymerase...Ch. 5 - Prob. 26RQCh. 5 - Prob. 27RQCh. 5 - Prob. 1FFT
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- What is the difference between a proto-oncogene and a tumor-suppressor gene?arrow_forwardDistinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do proto-oncogenes and tumor-suppressor genes undergo gain-of-function or loss-of-function mutations? Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, BCL-2, JUN, MDM2, and p16.arrow_forwardD) The level of carbon dioxide increases with the level of available oxygen. 60) The TPS3 gene provides instructions for making a protein called tumor protein p53. Known as the guardlan of the genome, this protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing t0o fast or in an uncontrolled way. The p53 protein is located in the nucleus of cells throughout the body, where it attaches directly to DNA and plays a critical role in determining whether the DNA will be repaired or the damaged cell will self- destruct (undergo apoptosis). If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. Suppose chromosomes in a skin cell are damaged by ultraviolet radiation. If the damaged genes do not affect p53, which choice correctly predict if the cell will become cancerous and why? No, the cell will not…arrow_forward
- How does the normal p53 protein inhibit cancer development?arrow_forwardWhat is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to cancer?arrow_forwardD) The level of carbon dioxide increases with the level of available oxygen. 60) The TP53 gene provides instructions for making a protein called tumor protein p53. Known as the guardian of the genome, this protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way. The p53 protein is located in the nucleus of cells throughout the body, where it attaches directly to DNA and plays a critical role in determining whether the DNA will be repaired or the damaged cell will self- destruct (undergo apoptosis). If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. eg Suppose chromosomes in a skin cell are damaged by ultraviolet radiation. If the damaged genes do not affect p53, which choice correctly predict if the cell will become cancerous and why? No, the cell will…arrow_forward
- How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the accumulation of genetic mutations in tumor-suppressor genes and proto-oncogenes?arrow_forwardHow does constitutively active Ras promote cancer?arrow_forwardCan restoring tumor suppressor function, such as mutant p53 or pRb, be used to cure cancer? If that's the case, how is it possible?arrow_forward
- What is a tumor suppressor? What is an oncogene?arrow_forwardWhy does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a cancerous phenotype, while it takes two mutations in tumor suppressor genes to lead to a cancerous phenotype?arrow_forwardwhy EGFR play a role in CRC and other cancer?arrow_forward
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