Explanation Given information: Hydrocodone bitartrate is a cough suppressant usually administrated in a 10 mg oral dose. The peak concentration of the drug in the blood occurs 1.3 hours after consumption and the peak concentration is 23.6 mg/ml. Formula used: The equation for the surge curve is y = a t e − b t , for positive constants a and b, increases rapidly and then decreases toward zero with a maximum at t = 1 b and the maximum is y = a b e . Calculation: The equation for the surge curve is y = a t e − b t . Given that the peak concentration of the drug in the blood occurs 1.3 hours after consumption. ⇒ t = 1.3 t = 1 b ⇒ b = 1 t ⇒ b = 1 1

6th Edition

ISBN: 9781119399353

Author: DA

Publisher: JOHN WILEY+SONS,INC.-CONSIGNMENT

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Chapter 4.8, Problem 5P

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The drug concentration curve for hydrocodonebitartrate.

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Chapter 4.8, Problem 4P

Chapter 4.8, Problem 6P

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Chapter 4 Solutions

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To draw: The drug concentration curve for hydrocodonebitartrate.

Solution Summary: The author explains the drug concentration curve for hydrocodone bitartrate. The peak concentration occurs 1.3 hours after consumption and the equation for the surge curve is y=ate-bt