Concept explainers
To discuss:
Dominant and recessive alleles; the difference between the homozygous and heterozygous individuals; why some alleles are homozygous; and others are heterozygous in a person.
Introduction:
DNA is a genetic material consisting of a long stretch of
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Anatomy and Physiology
- Mendelian Genetics and Non-Mendelian Genetics: Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jillian is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Jacobwhose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia. 1. Give the genotypes of Jillian and Jacob. Assuming that they will have 4 children, what is the probability that: 2. all their children will be normal? 3. they will have a son with Huntington’s disease? 4. they will have a daughter inflicted with both conditionsarrow_forwardWhy most loss-of-function mutant alleles are recessive to wild-type allelesarrow_forwardan example of a condition which is inherited via homozygous genes and one which is heterozygous. Do not use things like hair color or the color of Mendel’s pea plants here- discuss genetic disordersarrow_forward
- Difference between allelic variation and chromosomal abbreviationsarrow_forwardWhy a recessive trait can skip a generation,with examples; what is meant by a carrierarrow_forwardAchondroplasia, which is characterized by difficulty converting cartilage to bone and thus results in shortened limbs. This trait is autosomal dominant. (A = achondroplasia allele; a = average height allele.) A husband and wife both have achondroplasia. The couple have a total 12 living children: 6 boys and 6 girls. The husband is colorblind, which is an X-linked recessive trait, and the wife believes there is a chance she is a carrier of colorblindness, since that trait runs in her family. One of the couple’s daughters and three of their sons are colorblind. (Xc = colorblindness allele; XC = normal color vision allele.) a) Draw a Punnett square that illustrates the GENOTYPES of all of the children that could be CONCEIVED by this couple. b) What fraction of all of this couple's LIVING/SURVIVING children will have achondroplasia AND simultaneously be colorblind? c)arrow_forward
- Achondroplasia, which is characterized by difficulty converting cartilage to bone and thus results in shortened limbs. This trait is autosomal dominant. (A = achondroplasia allele; a = average height allele.) A husband and wife both have achondroplasia. The couple have a total 12 living children: 6 boys and 6 girls. The husband is colorblind, which is an X-linked recessive trait, and the wife believes there is a chance she is a carrier of colorblindness, since that trait runs in her family. One of the couple’s daughters and three of their sons are colorblind. (Xc = colorblindness allele; XC = normal color vision allele.) A. What are the complete genotypes of the husband and of the wife with respect to both colorblindness AND achondroplasia. Please EXPLAIN your answer. Be sure to indicate which genotype is that of the husband and which is that of the wife.arrow_forwardhow An inversion can affect phenotypearrow_forwardWhy the allele for cystic fibrosis is recessivearrow_forward
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